Alleviating neuronal inflammation induced by Aβ42 in SH-SY5Y through interaction with polysialic acid–oligomannuronate conjugate

Amyloid beta (Aβ) aggregation is one of the distinctive pathological hallmarks of Alzheimer's disease (AD). Therefore, the development of effective inhibitors against Aβ aggregate formation offers great promise for the treatment of AD. In this study, we designed a novel negatively charged functionalized conjugate aimed at inhibiting Aβ