Hybrid Nanoparticle–Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications

Hydrogel-based depots typically tend to remain where injected and have excellent biocompatibility but are relatively poor at controlling drug release. Nanoparticles (NPs) typically have the opposite properties. The smaller the NPs are, the more likely they are to leave the site of injection. Their biocompatibility is variable depending on the material but can be poor. However, NPs can be good at controlling drug release. In these and other properties, combining NPs and hydrogels can leverage their advantages and negate their disadvantages. This review highlights the rationale for hybrid NP–hydrogel systems in drug delivery, the basic methods of producing them, and examples where combining the two systems addressed specific problems.