[Venetoclax combined with dose-reduced HAD as induction treatment for patients with de-novo acute myeloid leukemia].

威尼斯人 髓系白血病 医学 白血病 髓样 肿瘤科 诱导疗法 内科学 癌症研究 化疗 慢性淋巴细胞白血病
作者
Zhengjian Yan,Y Li,Bin Zhang,Jingjing He,Jinxin Li,Shuning Wei,Sheng Wang,Q L Li,K Q Liu,Yingchang Mi
出处
期刊:PubMed 卷期号:45 (4): 387-390
标识
DOI:10.3760/cma.j.cn121090-20231208-00298
摘要

The efficacy and safety of venetoclax combined with reduced dose HAD regimen in the treatment of newly diagnosed acute myeloid leukemia (AML) was investigated. From May 2022 to January 2023, a total of 25 patients with newly diagnosed AML were treated with venetoclax combined with reduced-dose HAD regimen as induction therapy. Accoding to the 2017 ELN recommendations, 13 (52.0%) in favoable, 3 (12.0%) in intemediate, and 9 (36.0%) in adverse. The ORR (CR rate+PR rate) was 88.0%, and the CR rate was 84.0%. By May 30, 2023, with a median follow-up of 9 months, 1 year overall survival, event-free survival, and relapse-free survival were 100%, 94.7%, and 94.7%, respectively. All patients received 1-5 cycles of consolidation therapy and two median cycles. Treatment with venetoclax and reduced dose of HAD regimen in the treatment of patients with newly diagnosed AML was high effective and safe.

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