Biphasic Production of 5‐hydroxymethylfurfural (HMF) in a Recyclable Deep Eutectic Solvent‐based System Catalyzed by H4SiW12O40

The reaction with in situ extraction to yield 5-hydroxymethylfurfural (HMF) from d-fructose (Fru) was investigated using a biphasic system based on a self-consuming deep eutectic solvent (DES) as reaction phase. The significance of choline chloride (ChCl), a cost-effective and safe quaternary ammonium salt, was evident in enhancing HMF yield through fructose dehydration and concurrently suppressing side reactions. The DES system demonstrated fast reactions with high selecivities and recyclability across five cycles. The observed decline in H