植物雌激素
香豆素
雌激素受体
染料木素
交易激励
大豆黄酮
化学
异黄酮素
雌激素受体α
受体
兰克尔
内科学
雌激素
芹菜素
雌激素受体
内分泌学
药理学
生物化学
生物
转录因子
激活剂(遗传学)
医学
癌症
类黄酮
乳腺癌
基因
抗氧化剂
作者
Huiwon Seo,Hyeyeong Seo,Seok‐Hee Lee,Yooheon Park
标识
DOI:10.1016/j.ijbiomac.2024.134320
摘要
Phytoestrogens are plant-derived compounds that have chemical structures and functions similar to estrogen. Phytoestrogens act as ligand-inducible transcription factors involved in cellular growth by binding to estrogen receptors (ERs), specifically ER alpha (ERα) and beta (ERβ). Through this mechanism, phytoestrogens have a physiological function similar to that of the female hormone 17β-estradiol (E2), which can be useful in treating osteoporosis, cardiovascular disease, and cancer. Furthermore, phytoestrogens have been found to elicit various cellular responses depending on their affinity for ERs; in particular, they show a greater affinity with for ERβ. This study aimed to comprehensively analyze the mode of action of eight phytoestrogens, namely kaempferol, coumestrol, glycitein, apigenin, daidzein, genistein, equol, and resveratrol, by evaluating their estrogenic activity as ER ligands. Based on the bioluminescence resonance energy transfer (BRET)-based ER dimerization and transactivation assay results, all the phytoestrogens tested were identified as estrogen agonists by mediating ERα and ERβ dimerization. The specific binding and functions of ERα and ERβ were distinguished by differentiating between their dimerization activity. In addition, this study contributes to advancing our understanding of the overall mechanism of action involving both ERs.
科研通智能强力驱动
Strongly Powered by AbleSci AI