Hyaluronic acid-targeted dual-bubble/photothermal-driven nanomissile for enhanced “four-in-one” anti-tumor strategy

The dense extracellular matrix and high interstitial pressure affect the diffusion of nanodrug in tumor tissue, resulting in a small range of action of the active components in nanodrug, thereby affecting its anticancer efficacy. In order to enhance the diffusion ability of nanodrug, a dual-bubble/photothermal-driven nanomissile (HA@MnO