亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Silica particles convert thiol-containing molecules to disulfides

二氧化硅 介孔二氧化硅 激进的 水溶液 化学 分子 介孔材料 化学工程 氧化物 纳米材料 纳米技术 有机化学 材料科学 催化作用 工程类
作者
Yangjie Li,Kurt W. Kołasiński,Richard N. Zare
出处
期刊:Proceedings of the National Academy of Sciences of the United States of America [National Academy of Sciences]
卷期号:120 (34)
标识
DOI:10.1073/pnas.2304735120
摘要

Synthetic amorphous silica is a common food additive and a popular cosmetic ingredient. Mesoporous silica particles are also widely studied for their potential use in drug delivery and imaging applications because of their unique properties, such as tunable pore sizes, large surfaces areas, and assumed biocompatibility. Such a nanomaterial, when consisting of pure silicon dioxide, is generally considered to be chemically inert, but in this study, we showed that oxidation yields for different compounds were facilitated by simply incubating aqueous solutions with pure silica particles. Three thiol-containing molecules, L-cysteine, glutathione, and D-penicillamine, were studied separately, and it was found that more than 95% of oxidation happened after incubating any of these compounds with mesoporous silica particles in the dark for a day at room temperature. Oxidation increased over incubation time, and more oxidation was found for particles having larger surface areas. For nonporous silica particles at submicron ranges, yields of oxidation were different based on the structures of molecules, correlating with steric hindrance while accessing surfaces. We propose that the silyloxy radical (SiO•) on silica surfaces is what facilitates oxidation. Density functional theory calculations were conducted for total energy changes for reactions between different aqueous species and silicon dioxide surfaces. These calculations identified two most plausible pathways of the lowest energy to generate SiO• radicals from water radical cations H 2 O• + and hydroxyl radicals •OH, previously known to exist at water interfaces.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
杨怂怂完成签到 ,获得积分10
9秒前
13秒前
19秒前
朱朱子完成签到 ,获得积分10
1分钟前
Akim应助科研通管家采纳,获得10
1分钟前
GingerF应助科研通管家采纳,获得100
1分钟前
传奇3应助科研通管家采纳,获得10
1分钟前
1分钟前
1分钟前
1分钟前
Plum22发布了新的文献求助20
1分钟前
HAG完成签到,获得积分20
1分钟前
Perry完成签到,获得积分10
2分钟前
江枫渔火完成签到 ,获得积分10
2分钟前
MchemG应助科研通管家采纳,获得10
3分钟前
闫雪完成签到,获得积分10
3分钟前
3分钟前
闫雪发布了新的文献求助10
3分钟前
Plum22发布了新的文献求助20
3分钟前
直觉应助闫雪采纳,获得10
3分钟前
蚂蚁踢大象完成签到 ,获得积分10
4分钟前
hgsgeospan完成签到,获得积分10
5分钟前
直率的笑翠完成签到 ,获得积分10
5分钟前
hgs完成签到,获得积分10
5分钟前
5分钟前
MchemG应助科研通管家采纳,获得10
5分钟前
JamesPei应助科研通管家采纳,获得10
5分钟前
隐形曼青应助科研通管家采纳,获得10
5分钟前
Kevin完成签到,获得积分10
6分钟前
6分钟前
辉哥发布了新的文献求助10
6分钟前
6分钟前
6分钟前
董可以发布了新的文献求助10
6分钟前
英俊的铭应助董可以采纳,获得10
6分钟前
curtain完成签到,获得积分10
7分钟前
大个应助科研通管家采纳,获得10
7分钟前
MchemG应助科研通管家采纳,获得10
7分钟前
所所应助科研通管家采纳,获得10
7分钟前
科研通AI2S应助科研通管家采纳,获得10
7分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990105
求助须知:如何正确求助?哪些是违规求助? 3532119
关于积分的说明 11256456
捐赠科研通 3271016
什么是DOI,文献DOI怎么找? 1805171
邀请新用户注册赠送积分活动 882288
科研通“疑难数据库(出版商)”最低求助积分说明 809228