Calprotectin is a contributor to and potential therapeutic target for vascular calcification in chronic kidney disease

钙蛋白酶 医学 肾脏疾病 钙化 内科学 透析 生物标志物 胃肠病学 内分泌学 疾病 生物 生物化学 炎症性肠病
作者
Ana Amaya-Garrido,Manon Brunet,Bénédicte Buffin‐Meyer,Alexis Piedrafita,Lucile Grzesiak,Ezechiel Agbegbo,Arnaud Del Bello,Inès Ferrandiz,Şerban Ardeleanu,Marcelino Bermúdez-López,C. Fédou,Mylène Camus,Odile Burlet‐Schiltz,Jean Massines,Marie Buléon,Guylène Feuillet,Mélinda Alvès,Eric Neau,Audrey Casemayou,Benjamin Breuil
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science]
卷期号:15 (712) 被引量:24
标识
DOI:10.1126/scitranslmed.abn5939
摘要

Vascular calcification is an important risk factor for cardiovascular (CV) mortality in patients with chronic kidney disease (CKD). It is also a complex process involving osteochondrogenic differentiation of vascular smooth muscle cells (VSMCs) and abnormal deposition of minerals in the vascular wall. In an observational, multicenter European study, including 112 patients with CKD from Spain and 171 patients on dialysis from France, we used serum proteome analysis and further validation by ELISA to identify calprotectin, a circulating damage-associated molecular pattern protein, as being independently associated with CV outcome and mortality. This was confirmed in an additional cohort of 170 patients with CKD from Sweden, where increased serum calprotectin concentrations correlated with increased vascular calcification. In primary human VSMCs and mouse aortic rings, calprotectin exacerbated calcification. Treatment with paquinimod, a calprotectin inhibitor, as well as pharmacological inhibition of the receptor for advanced glycation end products and Toll-like receptor 4 inhibited the procalcifying effect of calprotectin. Paquinimod also ameliorated calcification induced by the sera of uremic patients in primary human VSMCs. Treatment with paquinimod prevented vascular calcification in mice with chronic renal failure induced by subtotal nephrectomy and in aged apolipoprotein E–deficient mice as well. These observations identified calprotectin as a key contributor of vascular calcification, and increased circulating calprotectin was strongly and independently associated with calcification, CV outcome, and mortality in patients with CKD. Inhibition of calprotectin might therefore be a promising strategy to prevent vascular calcification in patients with CKD.
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