已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Heterogeneous neuroimaging findings across substance use disorders localize to a common brain network

神经影像学 脑岛 神经科学 连接体 心理学 萎缩 医学 病理 功能连接
作者
Jacob L. Stubbs,Joseph J. Taylor,Shan Siddiqi,Frédéric Schaper,Alexander L. Cohen,William Drew,Colleen A. Hanlon,Amir Abdolahi,Henry Z. Wang,William G. Honer,William J. Panenka,Michael Fox
标识
DOI:10.1038/s44220-023-00128-7
摘要

Substance use disorders are associated with neuroimaging abnormalities, but results are heterogeneous across studies and vary across substances, and the causal interpretation of these abnormalities is unknown. We have used network mapping approaches and a functional connectome from a large cohort of healthy participants (n = 1,000) to test whether neuroimaging abnormalities across substance use disorders map to a common brain network. Starting with coordinates of regional brain atrophy from 45 studies (3,791 participants), we found that 91% of the neuroimaging findings mapped to a common brain network. This network was specific to substance use disorder compared to atrophy associated with normal aging and neurodegenerative disease (PFWE < 0.05). Coordinates of functional MRI abnormalities from 99 studies (5,256 participants) mapped to a similar brain network. We found no differences in networks across different substance use categories. We combined all substance use disorder data (144 studies, 9,047 participants) to generate an overall coordinate-based network for substance use disorder, which included positive connectivity to the anterior cingulate, bilateral insulae, dorsolateral prefrontal cortices and thalamus, and negative connectivity to the medial prefrontal and occipital cortices. Lesions resulting in remission from nicotine use disorder (n = 34) intersected this network significantly more than control lesions (n = 69; P < 0.0084). We conclude that neuroimaging abnormalities across substance use disorders map to a common brain network that is similar across imaging modalities, substances and lesion locations that cause remission from substance use disorders. In this study Stubbs et al. find that neuroimaging neuroimaging abnormalities across substance use disorders map to a common brain network that is similar across imaging modalities and substance use categories.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xiaolei完成签到 ,获得积分10
1秒前
2秒前
健忘数据线完成签到 ,获得积分10
3秒前
oxs完成签到 ,获得积分10
5秒前
完美世界应助科研通管家采纳,获得10
6秒前
斯文败类应助科研通管家采纳,获得10
6秒前
传奇3应助科研通管家采纳,获得10
6秒前
EVE完成签到,获得积分10
6秒前
天天快乐应助科研通管家采纳,获得10
6秒前
小二郎应助科研通管家采纳,获得10
6秒前
CipherSage应助科研通管家采纳,获得10
6秒前
文艺的念之完成签到 ,获得积分10
6秒前
踏实啤酒发布了新的文献求助30
8秒前
Yunis发布了新的文献求助10
9秒前
Alex给芯之痕的求助进行了留言
10秒前
nini完成签到,获得积分10
10秒前
10秒前
完美世界应助科研小白采纳,获得10
12秒前
U9A发布了新的文献求助20
16秒前
liuyanq发布了新的文献求助10
17秒前
18秒前
鱼羊明完成签到 ,获得积分10
20秒前
21秒前
21秒前
苏满天完成签到 ,获得积分10
22秒前
钱仙人完成签到,获得积分10
23秒前
liuyanq完成签到,获得积分10
23秒前
科研小白发布了新的文献求助10
23秒前
赵坤煊完成签到 ,获得积分10
25秒前
Husayn发布了新的文献求助10
25秒前
song发布了新的文献求助10
26秒前
ganjqly应助段盈采纳,获得20
27秒前
大胆隶完成签到,获得积分10
32秒前
科研小白完成签到,获得积分10
32秒前
U9A发布了新的文献求助20
33秒前
Zz发布了新的文献求助10
33秒前
35秒前
农夫完成签到,获得积分0
35秒前
段盈完成签到,获得积分10
37秒前
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976531
求助须知:如何正确求助?哪些是违规求助? 3520576
关于积分的说明 11204042
捐赠科研通 3257210
什么是DOI,文献DOI怎么找? 1798648
邀请新用户注册赠送积分活动 877835
科研通“疑难数据库(出版商)”最低求助积分说明 806555