生物相容性
静电纺丝
傅里叶变换红外光谱
没食子酸
抗菌剂
扫描电子显微镜
核化学
化学
材料科学
化学工程
复合材料
抗氧化剂
有机化学
聚合物
工程类
作者
Alexa-Maria Croitoru,Musa Ayran,Eray Altan,Yasin Karaçelebi,Songul Ulag,Ali Şahin,Mehmet Mücahit Güncü,Burak Aksu,Oğuzhan Gündüz,Bianca-Maria Tihăuan,Denisa Ficai,Anton Ficai
标识
DOI:10.1016/j.ijbiomac.2023.126996
摘要
In this study, novel fibers were designed based on ethylcellulose (EC), loaded with different concentrations of gallic acid (GA) using the electrospinning technique, in order to investigate the potential of these materials as wound dressings. The chemical structure and morphology, along with the antimicrobial and biocompatibility tests of the EC_GA fibers were investigated. To observe the chemical interactions between the components, fourier transform infrared spectroscopy (FTIR) was used. The morphological analyzes were performed using scanning electron microscope (SEM). The uniaxial tensile test machine was used to obtain mechanical performance of the fibers. MTT assay was applied to get the biocompatibility properties of the fibers and antimicrobial test was applied to obtain the antimicrobial activity of the fibers. Based on the obtained results, the highest viability value of 67.4 % was obtained for 10%EC_100GA on the third day of incubation, demonstrating that with the addition of a higher concentration of GA, the cell viability increases. The antimicrobial tests, evaluated against Staphylococcus (S.) aureus, Escherichia (E.) coli, Pseudomonas (Ps.) aeruginosa and Candida (C.) albicans, showed a >90 % microbial reduction capacity correlated with a logarithmic reduction ranging from 0.63 to 1, for 10%EC_100 GA. In vitro release tests of GA from the fibers showed that GA was totally released from 10%EC_100 GA fibers after 2880 min, demonstrating a controlled release profile. These findings demonstrated that EC_GA fibers may be suitable for application in biomedical fields such as wound dressing materials. However, further studies should be performed to increase the biocompatibility properties of the fibers.
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