Evolution of brain MRI lesions in paediatric myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and its relevance to disease course

医学 疾病 多发性硬化 髓鞘少突胶质细胞糖蛋白 少突胶质细胞 髓鞘 抗体 病理 脱髓鞘病 免疫学 中枢神经系统 内科学 实验性自身免疫性脑脊髓炎
作者
Omar Abdel‐Mannan,Dimitrios Champsas,Carmen Tur,Vanessa Lee,Sharmila Manivannan,Haroon Usman,Alison Skippen,Ishita Desai,Manali Chitre,Rob Forsyth,Rachel Kneen,Dipak Ram,Sithara Ramdas,Thomas Rossor,Siobhan West,Sukhvir Wright,Jacqueline Palace,Evangeline Wassmer,Cheryl Hemingway,Ming Lim,Kshitij Mankad,Olga Ciccarelli,Yael Hacohen
出处
期刊:Journal of Neurology, Neurosurgery, and Psychiatry [BMJ]
卷期号:: jnnp-332542 被引量:3
标识
DOI:10.1136/jnnp-2023-332542
摘要

Background Lesion resolution is often observed in children with myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and asymptomatic lesions are less commonly reported in MOGAD than in multiple sclerosis (MS). Objective We aimed to evaluate brain MRI changes over time in paediatric MOGAD. Methods Retrospective study in eight UK paediatric neuroscience centres. Acute brain MRI and available follow-up MRIs were reviewed. Predictors for lesion dynamic were evaluated using multivariable regression and Kaplan-Meier survival analyses were used to predict risk of relapse, disability and MOG-Ab status. Results 200 children were included (MOGAD 97; MS 103). At first MRI post attack, new symptomatic and asymptomatic lesions were seen more often in MS versus MOGAD (52/103 vs 28/97; p=0.002 and 37/103 vs 11/97; p<0.001); 83% of patients with MOGAD showed at least one lesion’s resolution at first follow‐up scan, and 23% had normal MRI. Only 1 patient with MS had single lesion resolution; none had normal MRI. Disappearing lesions in MOGAD were seen in 40% after the second attack, 21% after third attack and none after the fourth attack. New lesions at first follow-up scan were associated with increased likelihood of relapse (p=0.02) and persistent MOG-Ab serostatus (p=0.0016) compared with those with no new lesions. Plasma exchange was associated with increased likelihood of lesion resolution (p=0.01). Longer time from symptom onset to steroids was associated with increased likelihood of new lesions; 50% increase at 20 days (p=0.01). Conclusions These striking differences in lesion dynamics between MOGAD and MS suggest greater potential to repair. Early treatment with steroids and plasma exchange is associated with reduced likelihood of new lesions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
受伤凌蝶发布了新的文献求助10
1秒前
fusucheng完成签到,获得积分10
2秒前
koi完成签到,获得积分20
2秒前
2秒前
聪明摩托完成签到,获得积分10
2秒前
阿纯完成签到,获得积分10
3秒前
4秒前
肱二头肌完成签到,获得积分10
5秒前
6秒前
小王发布了新的文献求助10
6秒前
多情自古空余恨完成签到,获得积分10
7秒前
Qionglin完成签到,获得积分10
9秒前
Bao完成签到 ,获得积分10
10秒前
10秒前
初夏微凉发布了新的文献求助30
10秒前
11秒前
书霂完成签到,获得积分10
11秒前
优秀含羞草完成签到,获得积分10
12秒前
宓沂完成签到,获得积分10
12秒前
vivre223完成签到,获得积分10
12秒前
量子星尘发布了新的文献求助10
13秒前
受伤凌蝶完成签到,获得积分10
14秒前
wenjiejiang完成签到,获得积分10
15秒前
15秒前
zly完成签到 ,获得积分10
16秒前
16秒前
李某人完成签到,获得积分10
16秒前
17秒前
小鱼完成签到,获得积分10
18秒前
小崽总完成签到,获得积分10
18秒前
挽风完成签到,获得积分10
21秒前
21秒前
dxs发布了新的文献求助10
21秒前
苹果沛柔完成签到,获得积分10
22秒前
111完成签到 ,获得积分10
22秒前
Amon完成签到 ,获得积分10
23秒前
结实寄柔完成签到,获得积分10
24秒前
dh完成签到,获得积分0
24秒前
超帅鸭子发布了新的文献求助10
25秒前
苹果沛柔发布了新的文献求助10
26秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029