亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

pH-responsive LBL coated silica nanocarriers for controlled release of chlorhexidine.

纳米载体 聚电解质 涂层 烯丙胺 纳米颗粒 Zeta电位 聚丙烯酸 控制释放 化学 洗必泰 化学工程 材料科学 纳米技术 有机化学 聚合物 牙科 工程类 医学
作者
Yazan Al Thaher,Sharif Abdelghany,Samer R. Abulateefeh
出处
期刊:Colloids and Surfaces A: Physicochemical and Engineering Aspects [Elsevier BV]
卷期号:680: 132671-132671 被引量:6
标识
DOI:10.1016/j.colsurfa.2023.132671
摘要

As resistant microbial strains continue to appear, antibiotic-based therapies become less effective. Hence, development of non-antibiotic antimicrobial delivery systems, such as those containing chlorhexidine, is urgently needed for the prevention and treatment of infections. For many biological applications as well as for efficient therapy, controlling the release kinetics of these antimicrobials is crucial. In this study, chlorhexidine was loaded into silica nanoparticles via layer-by-layer (LbL) coating technique. Different polyelectrolytes including polyacrylic acid (PAA), poly(diallyldimethylammonium) chloride (PDDA), poly(allylamine hydrochloride) (PAH) and poly(4-styrenesulfonic acid) (PSS) were utilized in LbL coatings. Three types of coatings were studied: (1) PSS and PDDA (2) PAA and PAH (3) PSS and PAH. Zeta potential, transmission electron microscope, and a thermogravimetric analysis were used to characterize the nanoparticles. Acetate buffer pH 5 and PBS pH 7.4 were used as release media to assess the chlorhexidine release from nanoparticles. The chlorhexidine LbL-coated nanoparticles were effective in extending the duration of the medication release to 40 days. Chlorhexidine release was affected by pH of the release media and type of LbL coating, with a greater release at pH 5. PAA and PAH LbL coating had the highest amount of chlorhexidine release. This work illustrates that the LbL coating is an efficient technique for controlling the release of chlorhexidine from silica nanocarriers, with PAA and PAH coat being most effective among other polyelectrolytes tested. Different release profiles can be adapted for a variety of biomedical uses such as orthopedic or dental applications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
49秒前
50秒前
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
Ma发布了新的文献求助10
1分钟前
1分钟前
科研通AI5应助Ma采纳,获得10
1分钟前
忧伤的绍辉完成签到 ,获得积分10
1分钟前
隐形曼青应助易四夕采纳,获得10
1分钟前
2分钟前
易四夕发布了新的文献求助10
2分钟前
2分钟前
3分钟前
Ma发布了新的文献求助10
3分钟前
3分钟前
随机子发布了新的文献求助10
3分钟前
3分钟前
Ava应助科研通管家采纳,获得10
3分钟前
科目三应助科研通管家采纳,获得10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
Ma发布了新的文献求助10
3分钟前
Ma完成签到,获得积分10
4分钟前
4分钟前
易四夕发布了新的文献求助10
5分钟前
5分钟前
5分钟前
英姑应助王大壮采纳,获得10
5分钟前
SciGPT应助科研通管家采纳,获得10
5分钟前
5分钟前
5分钟前
5分钟前
Mine发布了新的文献求助10
5分钟前
王大壮发布了新的文献求助10
5分钟前
Mine完成签到,获得积分10
6分钟前
郗妫完成签到,获得积分10
6分钟前
王大壮发布了新的文献求助10
6分钟前
科研通AI5应助Mine采纳,获得30
6分钟前
6分钟前
852应助美好颜采纳,获得10
6分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167214
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638