聚乳酸
酵母
羟基烷酸
可生物降解聚合物
生物生产
生物塑料
生物技术
聚丁二酸丁二醇酯
代谢工程
环境污染
生物可分解塑胶
生物量(生态学)
制浆造纸工业
化学
环境科学
废物管理
生物
有机化学
生物化学
聚合物
细菌
高分子化学
环境保护
工程类
生态学
遗传学
酶
作者
Fengli Zhang,Lin Zhang,Duwen Zeng,Sha Liao,Yachao Fan,Verawat Champreda,Weerawat Runguphan,Xin‐Qing Zhao
标识
DOI:10.1016/j.biotechadv.2023.108222
摘要
Traditional plastic products have caused serious environmental pollution due to difficulty to be degraded in the natural environment. In the recent years, biodegradable plastics are receiving increasing attention due to advantages in natural degradability and environmental friendliness. Biodegradable plastics have potential to be used in food, agriculture, industry, medicine and other fields. However, the high production cost of such plastics is the bottleneck that limits their commercialization and application. Yeasts, including budding yeast and non-conventional yeasts, are widely studied to produce biodegradable plastics and their organic acid monomers. Compared to bacteria, yeast strains are more tolerable to multiple stress conditions including low pH and high temperature, and also have other advantages such as generally regarded as safe, and no phage infection. In addition, synthetic biology and metabolic engineering of yeast have enabled its rapid and efficient engineering for bioproduction using various renewable feedstocks, especially lignocellulosic biomass. This review focuses on the recent progress in biosynthesis technology and strategies of monomeric organic acids for biodegradable polymers, including polylactic acid (PLA), polyhydroxyalkanoate (PHA), polybutylene succinate (PBS), and polybutylene adipate terephthalate (PBAT) using yeast cell factories. Improving the performance of yeast as a cell factory and strategies to improve yeast acid stress tolerance are also discussed. In addition, the critical challenges and future prospects for the production of biodegradable plastic monomer using yeast are also discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI