体细胞
基因组不稳定性
生物
DNA损伤
DNA修复
基因组
遗传学
DNA
计算生物学
基因
作者
Stephanie Panier,Siyao Wang,Björn Schumacher
出处
期刊:Annual Review of Pathology-mechanisms of Disease
[Annual Reviews]
日期:2024-01-24
卷期号:19 (1): 261-290
被引量:3
标识
DOI:10.1146/annurev-pathmechdis-051122-093128
摘要
Genetic material is constantly subjected to genotoxic insults and is critically dependent on DNA repair. Genome maintenance mechanisms differ in somatic and germ cells as the soma only requires maintenance during an individual's lifespan, while the germline indefinitely perpetuates its genetic information. DNA lesions are recognized and repaired by mechanistically highly diverse repair machineries. The DNA damage response impinges on a vast array of homeostatic processes and can ultimately result in cell fate changes such as apoptosis or cellular senescence. DNA damage causally contributes to the aging process and aging-associated diseases, most prominently cancer. By causing mutations, DNA damage in germ cells can lead to genetic diseases and impact the evolutionary trajectory of a species. The mechanisms ensuring tight control of germline DNA repair could be highly instructive in defining strategies for improved somatic DNA repair. They may provide future interventions to maintain health and prevent disease during aging.
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