医学
主旨
穿孔
胃
前瞻性队列研究
临床终点
粘膜切除术
内科学
多中心研究
胃肠病学
切除缘
切除术
外科
间质细胞
临床试验
随机对照试验
材料科学
冲孔
冶金
作者
Satoki Shichijo,Noriya Uedo,Atsushi Sawada,Kingo Hirasawa,Hirohisa Takeuchi,Nobutsugu Abe,Masaki Miyaoka,Kenshi Yao,Akira Dobashi,Kazuki Sumiyama,Tsukasa Ishida,Yoshinori Morita,Hiroyuki Ono
摘要
Objectives Early gastric cancer endoscopic resection (ER) is prominent in Japan. However, evidence regarding ER of gastric submucosal tumors (SMT) is limited. This prospective multicenter phase II study investigated the efficacy and safety of endoscopic full‐thickness resection (EFTR) for gastric SMT. Methods Endoscopic full‐thickness resection indication for gastric SMT was 11–30 mm, histologically proven or clinically suspicious (irregular margin, increasing size, or internal heterogeneity) gastrointestinal stromal tumors (GIST), with no ulceration and intraluminal growth type. The primary end‐point was the complete ER (ER0) rate, with a sample size of 42. Results We enrolled 46 patients with 46 lesions between September 2020 and May 2023 at seven Japanese institutions. The mean ± SD (range) endoscopic tumor size was 18.8 ± 4.5 (11–28) mm. The tumor resection and defect closure times were 54 ± 26 (22–125) min and 33 ± 28 (12–186) min, respectively. A 100% ER0 was achieved in all 46 patients. The EFTR procedure was accomplished in all patients without surgical intervention. One patient had delayed perforation and was managed endoscopically. GIST accounted for 76% ( n = 35) of the cases. R0, R1, and RX rates were 33 (77%), 3 (6.5%), and 7 (15%), respectively. Conclusion Endoscopic full‐thickness resection for gastric SMT of 11–30 mm is efficacious. It warrants further validation in a large‐scale cohort study to determine the long‐term outcome of this treatment for patients with gastric GIST.
科研通智能强力驱动
Strongly Powered by AbleSci AI