脑膜
串扰
神经科学
生物
基底膜
病理
解剖
细胞生物学
医学
工程类
电子工程
作者
Christina N. Como,Sol Kim,Julie A. Siegenthaler
标识
DOI:10.1016/j.conb.2023.102676
摘要
The spatial and temporal development of the brain, overlying meninges (fibroblasts, vasculature and immune cells) and calvarium are highly coordinated. In particular, the timing of meningeal fibroblasts into molecularly distinct pia, arachnoid and dura subtypes coincides with key developmental events in the brain and calvarium. Further, the meninges are positioned to influence development of adjacent structures and do so via depositing basement membrane and producing molecular cues to regulate brain and calvarial development. Here, we review the current knowledge of how meninges development aligns with events in the brain and calvarium and meningeal fibroblast “crosstalk” with these structures. We summarize outstanding questions and how the use of non-mammalian models to study the meninges will substantially advance the field of meninges biology.
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