Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases

普氏粪杆菌 某种肠道细菌 阿克曼西亚 免疫系统 免疫学 医学 微生物群 免疫疗法 银屑病 肠道菌群 生物 拟杆菌 生物信息学 遗传学 细菌
作者
Raden Mohamad Rendy Ariezal Effendi,Muhammad Anshory,Handono Kalim,Reiva Farah Dwiyana,Oki Suwarsa,Luba M. Pardo,Tamar Nijsten,Hok Bing Thio
出处
期刊:Microorganisms [MDPI AG]
卷期号:10 (12): 2382-2382 被引量:18
标识
DOI:10.3390/microorganisms10122382
摘要

Probiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD). Akkermansia muciniphila (A. muciniphila) and Faecalibacterium prausnitzii (F. prausnitzii) are two different types of bacteria that play a significant part in this function. It has been established that Akkermansia and Faecalibacterium are abundant in normal populations and have protective benefits on digestive health while also enhancing the immune system, metabolism, and gut barrier of the host. They have the potential to be a therapeutic target in diseases connected to the microbiota, such as immunological disorders and cancer immunotherapy. There has not been a review of the anti-inflammatory effects of Akkermansia and Faecalibacterium, particularly in immunological diseases. In this review, we highlight the most recent scientific findings regarding A. muciniphila and F. prausnitzii as two significant gut microbiota for microbiome alterations and seek to provide cutting-edge insight in terms of microbiome-targeted therapies as promising preventive and therapeutic tools in immune-related diseases and cancer immunotherapy.
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