Nanozymes for biomedical applications in orthopaedics

As the next generation of artificial enzymes, nanozymes have attracted increasing attention in biomedical applications due to their multienzyme-like characteristics, multifunctionalities, low cost, and high stability. By taking advantage of their diverse activities, a growing number of nanozyme-mediated therapeutic strategies have been developed for various diseases. Herein, we provide a brief review of the representative studies of nanozymes, especially in orthopaedic diseases over the past decade, which include arthritis, osteoporosis, bone regeneration, bacteria-associated infections, and osteosarcoma. Moreover, the future potential applications and some major challenges are also discussed. This review would not only provide some instructive views of nanozymes but also promote the development of enzyme-mimetic strategies in orthopaedics.