Umbilical cord mesenchymal stem cell-derived extracellular vesicles improve excessive autophagy of granulosa cells through METTL3

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder impacting women’s fertility. The authors in this study using DHEA-induced granulosa cells (GCs) demonstrated that umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-MSC-EVs) suppressed PINK1/ Parkin-mediated mitophagy of ovarian GCs through METTL3, thereby improving PCOS.