CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T‐MRI

卡德西尔 白质 高强度 白质脑病 高碳酸血症 医学 白质疏松症 脑动脉 心脏病学 病理 大脑皮层 磁共振成像 解剖 内科学 放射科 呼吸系统
作者
Hilde van den Brink,Anna Kopczak,Tine Arts,Laurien Onkenhout,Jeroen C.W. Siero,Jaco J.M. Zwanenburg,Sandra Hein,Mathias Hübner,Benno Gesierich,Marco Duering,Michael Stringer,Jeroen Hendrikse,Joanna M. Wardlaw,Anne Joutel,Martin Dichgans,Geert Jan Biessels
出处
期刊:Annals of Neurology [Wiley]
卷期号:93 (1): 29-39 被引量:16
标识
DOI:10.1002/ana.26527
摘要

Objective Cerebral small vessel diseases (cSVDs) are a major cause of stroke and dementia. We used cutting‐edge 7T‐MRI techniques in patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), to establish which aspects of cerebral small vessel function are affected by this monogenic form of cSVD. Methods We recruited 23 CADASIL patients (age 51.1 ± 10.1 years, 52% women) and 13 age‐ and sex‐matched controls (46.1 ± 12.6, 46% women). Small vessel function measures included: basal ganglia and centrum semiovale perforating artery blood flow velocity and pulsatility, vascular reactivity to a visual stimulus in the occipital cortex and reactivity to hypercapnia in the cortex, subcortical gray matter, white matter, and white matter hyperintensities. Results Compared with controls, CADASIL patients showed lower blood flow velocity and higher pulsatility index within perforating arteries of the centrum semiovale (mean difference − 0.09 cm/s, p = 0.03 and 0.20, p = 0.009) and basal ganglia (mean difference − 0.98 cm/s, p = 0.003 and 0.17, p = 0.06). Small vessel reactivity to a short visual stimulus was decreased (blood‐oxygen‐level dependent [BOLD] mean difference −0.21%, p = 0.04) in patients, while reactivity to hypercapnia was preserved in the cortex, subcortical gray matter, and normal appearing white matter. Among patients, reactivity to hypercapnia was decreased in white matter hyperintensities compared to normal appearing white matter (BOLD mean difference −0.29%, p = 0.02). Interpretation Multiple aspects of cerebral small vessel function on 7T‐MRI were abnormal in CADASIL patients, indicative of increased arteriolar stiffness and regional abnormalities in reactivity, locally also in relation to white matter injury. These observations provide novel markers of cSVD for mechanistic and intervention studies. ANN NEUROL 2023;93:29–39
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Fengzhen007完成签到,获得积分10
4秒前
zz发布了新的文献求助10
4秒前
徐慕源完成签到,获得积分10
4秒前
博慧完成签到 ,获得积分10
6秒前
Nan发布了新的文献求助10
7秒前
害羞的雁易完成签到 ,获得积分10
9秒前
MM完成签到 ,获得积分10
10秒前
Rondab应助wwl采纳,获得10
11秒前
爱笑半雪完成签到,获得积分10
13秒前
玥瑶完成签到,获得积分20
14秒前
15秒前
科研小哥完成签到,获得积分10
17秒前
韶邑完成签到,获得积分10
18秒前
美丽心情发布了新的文献求助10
18秒前
昼尽夜临完成签到 ,获得积分10
18秒前
20秒前
jyy应助yy14207采纳,获得10
20秒前
观妙散人完成签到,获得积分10
21秒前
梅零落完成签到 ,获得积分10
21秒前
哈哈哈完成签到 ,获得积分10
22秒前
ihonest完成签到,获得积分10
22秒前
yulian发布了新的文献求助10
22秒前
dt发布了新的文献求助10
25秒前
keyan完成签到 ,获得积分10
26秒前
yyx完成签到 ,获得积分10
27秒前
老实怀蝶完成签到,获得积分10
30秒前
木瓜小五哥完成签到,获得积分10
30秒前
章鱼小丸子完成签到,获得积分10
30秒前
村上春树的摩的完成签到 ,获得积分10
31秒前
222关闭了222文献求助
31秒前
Damon完成签到 ,获得积分10
32秒前
wyhhh完成签到,获得积分10
32秒前
33秒前
zzuwxj完成签到,获得积分10
33秒前
YCu发布了新的文献求助10
34秒前
Rondab应助wwl采纳,获得10
36秒前
ma化疼没木完成签到,获得积分10
37秒前
寒冷丹雪完成签到,获得积分10
37秒前
bill完成签到,获得积分10
38秒前
CodeCraft应助yy14207采纳,获得10
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513400
关于积分的说明 11167585
捐赠科研通 3248853
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875131
科研通“疑难数据库(出版商)”最低求助积分说明 804664