Chromium-Catalyzed Three-Component Synthesis of Monofluoroalkenes from gem-Difluoroalkenes via C–O/C–H and C–F Bond Activation

We report here the chromium-catalyzed three-component defluorinative cross-couplings of gem-difluoroalkenes with benzyl 2-pyridinyl ethers and aryl Grignard reagents under mild conditions, enabling the convenient synthesis of diarylmethylated monofluoroalkenes in good chemo- and stereoselectivity.