Endometrioid adenocarcinoma: combined multiparametric MRI and tumour marker HE4 to evaluate tumour grade and lymphovascular space invasion

医学 接收机工作特性 有效扩散系数 磁共振成像 多参数磁共振成像 磁共振弥散成像 曲线下面积 核医学 病态的 曲线下面积 放射科 病理 内科学 前列腺 癌症 药代动力学
作者
Xiaoning Yue,Xuying He,Jingjing Wu,Weixin Fan,Zhang Hong-jie,C W Wang
出处
期刊:Clinical Radiology [Elsevier BV]
卷期号:78 (8): e574-e581 被引量:4
标识
DOI:10.1016/j.crad.2023.04.005
摘要

To assess the value of semi-quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and quantitative diffusion-weighted imaging parameters combined with human epididymis protein 4 (HE4) in predicting the pathological grade and lymphovascular space invasion (LVSI) of endometrioid adenocarcinoma (EAC).Between October 2018 and December 2021, 60 women (mean age, 55 [range, 32-77] years) with EAC underwent preoperative pelvic MRI and HE4 level measurements. The positive enhancement integral (PEI), time to peak, maximum slope of increase (MSI), and maximum slope of decrease were measured by manually drawing a region of interest on the neoplastic tissue. The receiver operating characteristic curve was used to calculate the diagnostic efficiency of the single parameter and combined factors.Lower apparent diffusion coefficients (ADCs) were observed in high-grade tumours (G3) than in low-grade tumours (G1/G2). PEI, MSI, and HE4 levels were higher in the high-grade tumours than in the low-grade tumours (p<0.05). The area under the curve (AUC) for G3 diagnosis using multiparametric MRI combined with HE4 was 0.929. ADC values were significantly lower in the EAC with LVSI than in those without LVSI. Tumours with LVSI showed higher PEI and HE4 levels than those without LVSI (p<0.05). The AUC for LVSI-positive diagnosis using multiparametric MRI combined with HE4 was 0.814.Semi-quantitative DCE-MRI, ADC values, and serum HE4 levels can be used to predict tumour grade and LVSI, and the prediction efficiency of multiparametric MRI combined with serum HE4 is better than that of any single factor.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Younglee完成签到,获得积分10
4秒前
4秒前
xiaoxuan完成签到,获得积分10
5秒前
6秒前
Garnieta完成签到,获得积分10
7秒前
彤光赫显发布了新的文献求助10
8秒前
8秒前
浔城游侠完成签到,获得积分10
9秒前
9秒前
失眠的板栗完成签到,获得积分10
10秒前
蝶步韶华发布了新的文献求助10
12秒前
Jay发布了新的文献求助10
12秒前
jbhb发布了新的文献求助10
14秒前
幸运星发布了新的文献求助10
17秒前
17秒前
17秒前
18秒前
20秒前
小王完成签到 ,获得积分10
23秒前
liuyunhao7207发布了新的文献求助10
23秒前
Nugget发布了新的文献求助10
23秒前
量子星尘发布了新的文献求助10
26秒前
蝶步韶华完成签到,获得积分10
26秒前
SciGPT应助wade采纳,获得10
28秒前
稳重水卉完成签到,获得积分10
31秒前
我是老大应助111采纳,获得10
32秒前
34秒前
情怀应助天真的高山采纳,获得10
35秒前
万能图书馆应助高木采纳,获得10
36秒前
积极以云完成签到,获得积分10
37秒前
37秒前
39秒前
CyrusSo524应助zzz采纳,获得10
40秒前
123完成签到,获得积分10
41秒前
兔子先生完成签到 ,获得积分10
42秒前
向日葵完成签到,获得积分10
44秒前
科研通AI5应助天天采纳,获得10
44秒前
彤光赫显完成签到,获得积分10
46秒前
long0809完成签到,获得积分10
49秒前
天天快乐应助段一帆采纳,获得10
51秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174