Endometrioid adenocarcinoma: combined multiparametric MRI and tumour marker HE4 to evaluate tumour grade and lymphovascular space invasion

医学 接收机工作特性 有效扩散系数 磁共振成像 多参数磁共振成像 磁共振弥散成像 曲线下面积 核医学 病态的 曲线下面积 放射科 病理 内科学 前列腺 癌症 药代动力学
作者
Xiaoning Yue,Xuying He,Jingjing Wu,Weixin Fan,Zhang Hong-jie,C W Wang
出处
期刊:Clinical Radiology [Elsevier BV]
卷期号:78 (8): e574-e581 被引量:4
标识
DOI:10.1016/j.crad.2023.04.005
摘要

To assess the value of semi-quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and quantitative diffusion-weighted imaging parameters combined with human epididymis protein 4 (HE4) in predicting the pathological grade and lymphovascular space invasion (LVSI) of endometrioid adenocarcinoma (EAC).Between October 2018 and December 2021, 60 women (mean age, 55 [range, 32-77] years) with EAC underwent preoperative pelvic MRI and HE4 level measurements. The positive enhancement integral (PEI), time to peak, maximum slope of increase (MSI), and maximum slope of decrease were measured by manually drawing a region of interest on the neoplastic tissue. The receiver operating characteristic curve was used to calculate the diagnostic efficiency of the single parameter and combined factors.Lower apparent diffusion coefficients (ADCs) were observed in high-grade tumours (G3) than in low-grade tumours (G1/G2). PEI, MSI, and HE4 levels were higher in the high-grade tumours than in the low-grade tumours (p<0.05). The area under the curve (AUC) for G3 diagnosis using multiparametric MRI combined with HE4 was 0.929. ADC values were significantly lower in the EAC with LVSI than in those without LVSI. Tumours with LVSI showed higher PEI and HE4 levels than those without LVSI (p<0.05). The AUC for LVSI-positive diagnosis using multiparametric MRI combined with HE4 was 0.814.Semi-quantitative DCE-MRI, ADC values, and serum HE4 levels can be used to predict tumour grade and LVSI, and the prediction efficiency of multiparametric MRI combined with serum HE4 is better than that of any single factor.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
小马甲应助Lam采纳,获得10
1秒前
JJXIONG完成签到,获得积分10
2秒前
河马发布了新的文献求助10
3秒前
3秒前
可爱的函函应助肖肖采纳,获得10
4秒前
CodeCraft应助平常的紫蓝采纳,获得10
4秒前
好宝宝完成签到,获得积分10
4秒前
3237924531发布了新的文献求助10
5秒前
hdy331完成签到,获得积分10
5秒前
完美世界应助123采纳,获得10
6秒前
6秒前
怕孤独的忆南完成签到,获得积分10
8秒前
追风完成签到 ,获得积分10
9秒前
9秒前
yao完成签到,获得积分10
9秒前
常芹发布了新的文献求助10
10秒前
ED应助科研路漫漫采纳,获得10
10秒前
11秒前
布鲁克完成签到,获得积分10
12秒前
12秒前
量子星尘发布了新的文献求助10
13秒前
今后应助朴实的绣连采纳,获得30
13秒前
<小天才>发布了新的文献求助10
15秒前
15秒前
16秒前
Smy完成签到 ,获得积分10
16秒前
在水一方应助梁晓雯采纳,获得10
17秒前
Yy123发布了新的文献求助10
17秒前
tao发布了新的文献求助10
17秒前
3237924531完成签到,获得积分10
17秒前
健忘小霜完成签到,获得积分10
18秒前
19秒前
scholar完成签到,获得积分10
20秒前
wei发布了新的文献求助10
20秒前
鳗鱼灵阳完成签到,获得积分20
21秒前
21秒前
22秒前
无情的聋五完成签到 ,获得积分10
22秒前
Owen应助QQiang6采纳,获得10
23秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988838
求助须知:如何正确求助?哪些是违规求助? 3531250
关于积分的说明 11252914
捐赠科研通 3269838
什么是DOI,文献DOI怎么找? 1804820
邀请新用户注册赠送积分活动 881943
科研通“疑难数据库(出版商)”最低求助积分说明 809028