神经肽
神经肽Y受体
生物
受体
功能(生物学)
G蛋白偶联受体
平衡
计算生物学
神经科学
生物信息学
细胞生物学
内分泌学
生物化学
作者
Mingxia Wang,Lei Wang,Wei Xu,Ziqiang Chu,Hengzhi Wang,Jingxiang Lu,Zhidong Xue,Yan Wang
标识
DOI:10.1016/j.jmb.2023.168416
摘要
Neuropeptides not only work through nervous system but some of them also work peripherally to regulate numerous physiological processes. They are important in regulation of numerous physiological processes including growth, reproduction, social behavior, inflammation, fluid homeostasis, cardiovascular function, and energy homeostasis. The various roles of neuropeptides make them promising candidates for prospective therapeutics of different diseases. Currently, NeuroPep has been updated to version 2.0, it now holds 11,417 unique neuropeptide entries, which is nearly double of the first version of NeuroPep. When available, we collected information about the receptor for each neuropeptide entry and predicted the 3D structures of those neuropeptides without known experimental structure using AlphaFold2 or APPTEST according to the peptide sequence length. In addition, DeepNeuropePred and NeuroPred-PLM, two neuropeptide prediction tools developed by us recently, were also integrated into NeuroPep 2.0 to help to facilitate the identification of new neuropeptides. NeuroPep 2.0 is freely accessible at https://isyslab.info/NeuroPepV2/.
科研通智能强力驱动
Strongly Powered by AbleSci AI