Geniposide improves depression-like behavior in prenatal stress male offspring through restoring HPA axis- and glucocorticoid receptor-associated dysfunction

后代 内分泌学 行为绝望测验 内科学 糖皮质激素受体 产前应激 开阔地 糖皮质激素 下丘脑-垂体-肾上腺轴 受体 促肾上腺皮质激素释放激素 海马体 抗抑郁药 高架加迷宫 心理学 激素 医学 生物 焦虑 怀孕 精神科 遗传学
作者
Yu Ma,Shun xin Li,Rui Zhou,Lin Deng,Wen He,Liangdan Guo,Lin Wang,Jia hui Hao,Li Yang,Min feng Fang,Yan Jun Cao
出处
期刊:Life Sciences [Elsevier]
卷期号:340: 122434-122434 被引量:2
标识
DOI:10.1016/j.lfs.2024.122434
摘要

Prenatal stress (PS) has an important impact on the brain development of offspring, which can lead to attention deficits, anxiety and depression in offspring. Geniposide (GE) is a kind of iridoid glycoside extracted from Gardenia jasminoides Ellis. It has various pharmacological effects and has been proved that have antidepressant effects. The aim of this study was to investigate the effect of GE on depression-like behavior in PS-induced male offspring mice and explore the possible molecular mechanisms. We used a prenatal restraint stress model, focusing on male PS-induced offspring mice to study the effects of GE. The results showed that GE administration for 4 weeks significantly improved the depression-like behavior in PS offspring mice, which was manifested by markedly increasing the sucrose preference of PS offspring and the activity in the open field test, and reducing the immobility time in the forced swimming test. In addition, GE significantly reduced the levels of hypothalamic-pituitary-adrenal (HPA) axis-related hormones and exceedingly increased the protein expression of MAP2 and GAP43 in PS offspring. Furthermore, GE increased Glucocorticoid receptors (GR) nuclear translocation in the hippocampus of PS offspring, and enhanced the expression of synaptic plasticity-related proteins. The results of this study showed that GE exerts antidepressant effects in male PS offspring mice by regulating the HPA axis, GR function and proteins related to synaptic plasticity.
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