Effects of intermittent fasting regimens on glycemic, hepatic, anthropometric, and clinical markers in patients with non-alcoholic fatty liver disease: Systematic review and meta-analysis of randomized controlled trials

医学 内科学 脂肪肝 荟萃分析 胃肠病学 随机对照试验 脂肪变性 甘油三酯 血糖性 体质指数 疾病 胰岛素 胆固醇
作者
Saleh A. K. Saleh,Heitor O. Santos,Mihnea‐Alexandru Găman,Henrique Santa Capita Cerqueira,Eman Abbas Zaher,Wafa Romaih Alromaih,Norah Saud Arafat,A. Adi,Heba M. Adly,Reem Alyoubi,Naseem Alyahyawi,Hamed Kord‐Varkaneh
出处
期刊:Clinical nutrition ESPEN [Elsevier]
卷期号:59: 70-80 被引量:5
标识
DOI:10.1016/j.clnesp.2023.11.009
摘要

Summary

Objectives

Intermittent fasting (IF) regimens have been hypothesized to influence several markers of cardiometabolic and liver function. The objective of our meta-analysis was to investigate the impact of IF regimens on cardiometabolic and liver markers in subjects diagnosed with non-alcoholic fatty liver disease (NAFLD).

Methods

We searched several online databases (PubMed/Medline, Web of Science, Scopus and Embase) in order to identify suitable publications for inclusion in the meta-analysis. Results were expressed as weighted mean differences (WMD).

Results

From 12343 articles identified in different databases, a total of 7 RCT arms were entered into the quantitative synthesis. The manuscripts were published between 2019 and 2023. IF regimens (the 5:2 diet, 16/8 time-restricting feeding, and alternate day fasting) varied from 2 months to 3 months. IF regimens reduced steatosis scores (WMD: −33.22 CAP dB/m, 95 % CI: −50.72 to −15.72), anthropometric characteristics of obesity (WMD: −0.77 kg/m2, 95 % CI: −1.38 to −0.17 for body mass index; WMD: −3.16 kg, 95 % CI: −4.71 to −1.61 for body weight; WMD: −1.90 kg, 95 % CI: −3.51 to −0.29 for waist circumference), as well as ALT (WMD: −9.10 U/L, 95 % CI: −12.45 to −5.75), triglyceride (WMD: −20.83 mg/dl, 95 % CI: −39.01 to −2.66), total cholesterol (WMD: −7.80 mg/dl, 95 % CI: −15.18), HbA1c (WMD: −0.14 %, 95 % CI: −0.20 to −0.08) and HOMA-IR (WMD: −1.21, 95 % CI: −2.08 to −0.34) levels versus controls. Nevertheless, no between-group differences were detected for other biomarkers, e.g., fasting blood glucose, insulin, AST, HDL-C or LDL-C values, and fibrosis scores.

Conclusion

IF regimens can improve some markers of cardiometabolic and liver function in patients with NAFLD. However, the available evidence to support the benefits of IF regimens is limited and derived from a small number of studies, thus further research is needed to clarify the impact of IF on the cardiometabolic health of NAFLD patients.
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