糖尿病肾病
GDF15型
狼疮性肾炎
肾
肾干细胞
肾脏疾病
肾功能
肾病
内科学
人口
医学
内分泌学
生物
免疫学
糖尿病
疾病
干细胞
细胞生物学
祖细胞
环境卫生
作者
Charlotte Delrue,Reinhart Speeckaert,Joris R. Delanghe,Marijn M. Speeckaert
出处
期刊:Advances in Clinical Chemistry
日期:2023-01-01
卷期号:: 1-46
被引量:10
标识
DOI:10.1016/bs.acc.2023.02.003
摘要
Growth differentiation factor-15 (GDF-15) is a GDF subfamily member with potential kidney protective functions. Its nephroprotective activity is associated with both inflammation downregulation and upregulation of nephroprotective factors with anti-inflammatory activity, such as Klotho in tubular cells. However, GDF-15 has diverse and partially opposing functions depending on the state of the cells and the microenvironment. Increased GDF-15 levels have been linked to an increased risk of incident chronic kidney disease and a faster decline in kidney function in various renal disorders, including diabetic nephropathy, IgA nephropathy, lupus nephritis, anti-glomerular basement membrane nephritis, primary membranous nephropathy, kidney transplantation, Fabry disease and amyloidosis. The mechanisms underlying these effects are not yet fully understood. In this review, we will summarize GDF-15's potential role as a biomarker for kidney function in the general population, as well as in some specific kidney diseases.
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