D-dimer levels predict the treatment efficacy and prognosis of esophageal squamous cell carcinoma treated with PD-1/PD-L1 inhibitors

内科学 医学 比例危险模型 纤维蛋白原 D-二聚体 肿瘤科 胃肠病学 食管鳞状细胞癌
作者
Yuchen Wu,Xin Liu,Huihui Li,Wenjing Wang,Lisha Ye,Yun Zhou,Da Chen
出处
期刊:International Journal of Biological Markers [SAGE Publishing]
卷期号:39 (3): 209-216
标识
DOI:10.1177/03936155241262045
摘要

Objectives This study aimed to explore the value of D-dimer levels in predicting the treatment efficacy and prognosis of advanced esophageal squamous cell carcinoma (ESCC) treated with programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors. Methods The study retrospectively analyzed 233 ESCC patients who received PD-1/PD-L1 inhibitors. The optimal cut-off values for platelets, fibrinogen, and D-dimer were calculated based on maximally selected rank statistics for patients’ overall survival. Univariate and multivariate analyses of progression-free survival and overall survival were conducted by Cox proportional hazards regression model. Subgroup analyses of D-dimer levels in different fibrinogen levels were performed by log-rank test. Results The multivariate Cox regression analyses demonstrated that ESCC patients with D-dimer levels > 236 ng/mL exhibited both poorer progression-free survival ( P = 0.004) and overall survival ( P < 0.0001) compared to those with low D-dimer levels. The subgroup analyses further indicated that in the group of low fibrinogen levels, the higher D-dimer levels of ESCC patients exhibited significantly shorter progression-free survival ( P = 0.0021) and overall survival ( P < 0.0001). Conclusions The study revealed that the D-dimer levels possess predictive value for the treatment efficacy and prognosis of ESCC patients treated with PD-1/PD-L1 inhibitors.
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