鼠李糖乳杆菌
材料科学
再生(生物学)
益生菌
胞外聚合物
活性氧
生物膜
微生物学
纳米技术
生物
细胞生物学
细菌
遗传学
作者
Miao Qin,Xiumei Zhang,Haiyang Ding,Yanbai Chen,Wenxuan He,Yan Wei,Weiyi Chen,Yau Kei Chan,Yiwei Shi,Di Huang,Yi Deng
标识
DOI:10.1002/adma.202402530
摘要
Abstract The compact three‐dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration of antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm‐associated infections. To address this challenge, a solution is proposed: a probiotic bio‐heterojunction (P‐bioHJ) combining Lactobacillus rhamnosus with MXene (Ti 3 C 2 ) quantum dots (MQDs)/FeS heterojunction. This innovation aims to break down the saccharides in EPS, enabling effective combat against biofilm‐associated infections. Initially, the P‐bioHJ targets saccharides through metabolic processes, causing the collapse of EPS and allowing infiltration into bacterial colonies. Simultaneously, upon exposure to near‐infrared (NIR) irradiation, the P‐bioHJ produces reactive oxygen species (ROS) and thermal energy, deploying physical mechanisms to combat bacterial biofilms effectively. Following antibiofilm treatment, the P‐bioHJ adjusts the oxidative environment, reduces wound inflammation by scavenging ROS, boosts antioxidant enzyme activity, and mitigates the NF‐κB inflammatory pathway, thereby accelerating wound healing. In vitro and in vivo experiments confirm the exceptional antibiofilm, antioxidant/anti‐inflammatory, and wound‐regeneration properties of P‐bioHJ. In conclusion, this study provides a promising approach for treating biofilm‐related infections.
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