化学
芳基
催化作用
镍
组合化学
联轴节(管道)
对偶(语法数字)
有机化学
烷基
机械工程
艺术
文学类
工程类
作者
Xia Ge,Haojie Ji,Hongjian Lu
标识
DOI:10.1002/cjoc.202400276
摘要
Comprehensive Summary Unsymmetrical diarylamines are crucial components in many pharmaceuticals and functional materials. In this study, we introduce an efficient Chan‐Lam cross‐coupling method that utilizes phenylboronic acids and aryl azides as coupling agents in a redox‐neutral environment, enabled by a synergistic nickel/photoredox catalytic system. This approach leverages a proton‐coupled electron transfer mechanism to bypass the typical nitrene pathway associated with aryl azides, which is prone to intramolecular rearrangement, C—H amination, and reductive hydrogenation. Notably, our method exhibits broad compatibility with a variety of functional groups, including those derived from pharmaceuticals, demonstrating its versatile potential in organic synthesis and drug modification.
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