Sex-Specific Entorhinal Cortex Functional Connectivity in Cognitively Normal Older Adults with Amyloid-β Pathology

默认模式网络 载脂蛋白E 内嗅皮质 心理学 神经科学 神经学 颞叶 认知 疾病 医学 海马体 内科学 癫痫
作者
Liang Gong,Duan Liu,Bei Zhang,Siyi Yu,Chunhua Xi
出处
期刊:Molecular Neurobiology [Springer Nature]
被引量:1
标识
DOI:10.1007/s12035-024-04243-z
摘要

Abstract Sex and apolipoprotein E (APOE) genotype have been shown to influence the risk and progression of Alzheimer’s disease (AD). However, the impact of these factors on the functional connectivity of the entorhinal cortex (ERC) in clinically unpaired older adults (CUOA) with amyloid-β (Aβ +) pathology remains unclear. A total of 1022 cognitively normal older adults with Aβ + (603 females and 586 APOE ε4 +) from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) study were included in this study. The 2 × 2 (gender, 2 APOE genotypes) analysis of covariance was performed to compare the demographic information, cognitive performance, and volumetric MRI data among these groups. Voxel-wise comparisons of bilateral ERC functional connectivity (FC) were conducted, and partial correlation analyses were used to explore the associations between cognitive performance and ERC-FC strength. We found that the APOE genotype influenced ERC functional connectivity mainly in the sensorimotor network (SMN). Males exhibited higher ERC-FC in the salience network (SN), while females displayed higher ERC-FC in the default mode network (DMN), executive control network (ECN), and reward network. The interplay of sex and APOE genotype on ERC-FC was observed in the SMN and cerebellar lobe. The ERC-FC was associated with executive function and memory performance in individuals with CUOA-Aβ + . Our findings provide evidence of sex-specific ERC functional connectivity compensation mechanism in cognitively normal older adults with Aβ + pathology. This study may contribute to a better understanding of the mechanisms underlying the early stages of AD and may help develop personalized interventions in preclinical AD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
善学以致用应助Schiller采纳,获得10
2秒前
大模型应助哈哈采纳,获得10
3秒前
3秒前
zshjwk18完成签到,获得积分10
5秒前
慕青应助dong采纳,获得10
6秒前
莫愁发布了新的文献求助10
7秒前
小困完成签到 ,获得积分10
10秒前
12秒前
12秒前
不配.给李_的求助进行了留言
13秒前
晏啊完成签到,获得积分10
14秒前
张恒发布了新的文献求助30
16秒前
汉堡包应助野性的凌瑶采纳,获得10
17秒前
tuanheqi应助2028847955采纳,获得50
18秒前
shaohua2011发布了新的文献求助10
18秒前
幽默的花瓣完成签到,获得积分10
19秒前
20秒前
21秒前
科研通AI2S应助白华苍松采纳,获得10
22秒前
tsuki完成签到 ,获得积分10
23秒前
24秒前
刘成财发布了新的文献求助10
24秒前
25秒前
25秒前
27秒前
英姑应助TDMS采纳,获得20
27秒前
27秒前
27秒前
29秒前
29秒前
29秒前
dong发布了新的文献求助10
31秒前
33秒前
谨慎萤发布了新的文献求助10
33秒前
volvoamg发布了新的文献求助10
35秒前
明理的天抒完成签到 ,获得积分10
35秒前
38秒前
毛豆爸爸应助珊熙采纳,获得10
39秒前
39秒前
39秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3186420
求助须知:如何正确求助?哪些是违规求助? 2836740
关于积分的说明 8010808
捐赠科研通 2499065
什么是DOI,文献DOI怎么找? 1334061
科研通“疑难数据库(出版商)”最低求助积分说明 637023
邀请新用户注册赠送积分活动 604986