Sex-Specific Entorhinal Cortex Functional Connectivity in Cognitively Normal Older Adults with Amyloid-β Pathology

默认模式网络 载脂蛋白E 内嗅皮质 心理学 神经科学 神经学 颞叶 认知 疾病 医学 海马体 内科学 癫痫
作者
Liang Gong,Duan Liu,Bei Zhang,Siyi Yu,Chunhua Xi
出处
期刊:Molecular Neurobiology [Springer Nature]
被引量:1
标识
DOI:10.1007/s12035-024-04243-z
摘要

Abstract Sex and apolipoprotein E (APOE) genotype have been shown to influence the risk and progression of Alzheimer’s disease (AD). However, the impact of these factors on the functional connectivity of the entorhinal cortex (ERC) in clinically unpaired older adults (CUOA) with amyloid-β (Aβ +) pathology remains unclear. A total of 1022 cognitively normal older adults with Aβ + (603 females and 586 APOE ε4 +) from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) study were included in this study. The 2 × 2 (gender, 2 APOE genotypes) analysis of covariance was performed to compare the demographic information, cognitive performance, and volumetric MRI data among these groups. Voxel-wise comparisons of bilateral ERC functional connectivity (FC) were conducted, and partial correlation analyses were used to explore the associations between cognitive performance and ERC-FC strength. We found that the APOE genotype influenced ERC functional connectivity mainly in the sensorimotor network (SMN). Males exhibited higher ERC-FC in the salience network (SN), while females displayed higher ERC-FC in the default mode network (DMN), executive control network (ECN), and reward network. The interplay of sex and APOE genotype on ERC-FC was observed in the SMN and cerebellar lobe. The ERC-FC was associated with executive function and memory performance in individuals with CUOA-Aβ + . Our findings provide evidence of sex-specific ERC functional connectivity compensation mechanism in cognitively normal older adults with Aβ + pathology. This study may contribute to a better understanding of the mechanisms underlying the early stages of AD and may help develop personalized interventions in preclinical AD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
辞忧完成签到 ,获得积分10
刚刚
西瓜完成签到 ,获得积分10
刚刚
Jasper应助gjt采纳,获得10
2秒前
sjerry完成签到,获得积分20
2秒前
传奇3应助oaixlittle采纳,获得10
2秒前
霸气若菱发布了新的文献求助20
2秒前
2秒前
简qiu发布了新的文献求助10
3秒前
xxchang完成签到 ,获得积分10
3秒前
Ann发布了新的文献求助20
3秒前
王大橘完成签到 ,获得积分10
3秒前
丰知然应助二货采纳,获得10
4秒前
实现零完成签到 ,获得积分10
4秒前
popcorn完成签到 ,获得积分10
4秒前
hui完成签到,获得积分10
4秒前
伶俐夏兰完成签到 ,获得积分10
4秒前
sjerry发布了新的文献求助10
5秒前
22发布了新的文献求助10
6秒前
希望天下0贩的0应助小威采纳,获得10
6秒前
鳗鱼饭完成签到,获得积分10
6秒前
7秒前
李心雨发布了新的文献求助20
7秒前
8秒前
8秒前
8秒前
8秒前
Jasper应助微笑的严青采纳,获得10
8秒前
张航完成签到,获得积分10
9秒前
Hello应助幸福的凡灵采纳,获得10
9秒前
10秒前
魏106047完成签到,获得积分10
11秒前
keira发布了新的文献求助10
11秒前
11秒前
Jenny发布了新的文献求助30
11秒前
33发布了新的文献求助10
11秒前
11秒前
愉快谷芹完成签到,获得积分10
11秒前
和谐雁荷完成签到 ,获得积分10
12秒前
Cean完成签到,获得积分10
12秒前
vivianzhang完成签到,获得积分10
13秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3197609
求助须知:如何正确求助?哪些是违规求助? 2846409
关于积分的说明 8059057
捐赠科研通 2511243
什么是DOI,文献DOI怎么找? 1343188
科研通“疑难数据库(出版商)”最低求助积分说明 639536
邀请新用户注册赠送积分活动 609073