Sex-Specific Entorhinal Cortex Functional Connectivity in Cognitively Normal Older Adults with Amyloid-β Pathology

默认模式网络 载脂蛋白E 内嗅皮质 心理学 神经科学 神经学 颞叶 认知 疾病 医学 海马体 内科学 癫痫
作者
Liang Gong,Duan Liu,Bei Zhang,Siyi Yu,Chunhua Xi
出处
期刊:Molecular Neurobiology [Springer Nature]
被引量:1
标识
DOI:10.1007/s12035-024-04243-z
摘要

Abstract Sex and apolipoprotein E (APOE) genotype have been shown to influence the risk and progression of Alzheimer’s disease (AD). However, the impact of these factors on the functional connectivity of the entorhinal cortex (ERC) in clinically unpaired older adults (CUOA) with amyloid-β (Aβ +) pathology remains unclear. A total of 1022 cognitively normal older adults with Aβ + (603 females and 586 APOE ε4 +) from the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s (A4) study were included in this study. The 2 × 2 (gender, 2 APOE genotypes) analysis of covariance was performed to compare the demographic information, cognitive performance, and volumetric MRI data among these groups. Voxel-wise comparisons of bilateral ERC functional connectivity (FC) were conducted, and partial correlation analyses were used to explore the associations between cognitive performance and ERC-FC strength. We found that the APOE genotype influenced ERC functional connectivity mainly in the sensorimotor network (SMN). Males exhibited higher ERC-FC in the salience network (SN), while females displayed higher ERC-FC in the default mode network (DMN), executive control network (ECN), and reward network. The interplay of sex and APOE genotype on ERC-FC was observed in the SMN and cerebellar lobe. The ERC-FC was associated with executive function and memory performance in individuals with CUOA-Aβ + . Our findings provide evidence of sex-specific ERC functional connectivity compensation mechanism in cognitively normal older adults with Aβ + pathology. This study may contribute to a better understanding of the mechanisms underlying the early stages of AD and may help develop personalized interventions in preclinical AD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
香蕉觅云应助闪闪不言采纳,获得10
3秒前
爆米花应助眼睛大笑卉采纳,获得10
6秒前
xiaozhao完成签到,获得积分10
6秒前
天真无招发布了新的文献求助10
7秒前
lancetwu完成签到,获得积分10
9秒前
9秒前
李爱国应助寂寞有声采纳,获得30
10秒前
10秒前
11秒前
英姑应助虚心黄蜂采纳,获得10
11秒前
11秒前
12秒前
叮咚驳回了Wy应助
12秒前
13秒前
13秒前
Hello应助灵巧墨镜采纳,获得10
15秒前
Welcome发布了新的文献求助10
15秒前
zhaomr发布了新的文献求助20
16秒前
16秒前
17秒前
18秒前
18秒前
调研昵称发布了新的文献求助10
18秒前
芥9发布了新的文献求助10
18秒前
林先生完成签到,获得积分10
19秒前
19秒前
852应助Goldensun采纳,获得10
20秒前
pharpan发布了新的文献求助30
23秒前
调研昵称发布了新的文献求助10
24秒前
CodeCraft应助tonghau895采纳,获得10
25秒前
26秒前
11xxyy关注了科研通微信公众号
26秒前
Godlove发布了新的文献求助10
26秒前
jiabaoyu完成签到 ,获得积分10
27秒前
28秒前
28秒前
nenoaowu发布了新的文献求助10
31秒前
maibaobao发布了新的文献求助10
32秒前
pharpan完成签到,获得积分10
32秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183276
求助须知:如何正确求助?哪些是违规求助? 2833432
关于积分的说明 7993965
捐赠科研通 2495516
什么是DOI,文献DOI怎么找? 1331557
科研通“疑难数据库(出版商)”最低求助积分说明 636352
邀请新用户注册赠送积分活动 603509