Early signs of neurodegenerative diseases: Possible mechanisms and targets for Golgi stress

神经科学 高尔基体 生物 细胞生物学 内质网
作者
Mengyu Liu,Ying Duan,Jianru Dong,Kaisong Zhang,Xin Jin,Menglin Gao,Huachao Jia,Ju Chen,Mingyan Liu,Minjie Wei,Xin Zhong
出处
期刊:Biomedicine & Pharmacotherapy [Elsevier BV]
卷期号:175: 116646-116646 被引量:3
标识
DOI:10.1016/j.biopha.2024.116646
摘要

The Golgi apparatus plays a crucial role in mediating the modification, transport, and sorting of intracellular proteins and lipids. The morphological changes occurring in the Golgi apparatus are exceptionally important for maintaining its function. When exposed to external pressure or environmental stimulation, the Golgi apparatus undergoes adaptive changes in both structure and function, which are known as Golgi stress. Although certain signal pathway responses or post-translational modifications have been observed following Golgi stress, further research is needed to comprehensively summarize and understand the related mechanisms. Currently, there is evidence linking Golgi stress to neurodegenerative diseases; however, the role of Golgi stress in the progression of neurodegenerative diseases such as Alzheimer's disease remains largely unexplored. This review focuses on the structural and functional alterations of the Golgi apparatus during stress, elucidating potential mechanisms underlying the involvement of Golgi stress in regulating immunity, autophagy, and metabolic processes. Additionally, it highlights the pivotal role of Golgi stress as an early signaling event implicated in the pathogenesis and progression of neurodegenerative diseases. Furthermore, this study summarizes prospective targets that can be therapeutically exploited to mitigate neurodegenerative diseases by targeting Golgi stress. These findings provide a theoretical foundation for identifying novel breakthroughs in preventing and treating neurodegenerative diseases.
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