表观遗传学
DNA甲基化
痴呆
发病机制
机制(生物学)
疾病
生物
甲基化
阿尔茨海默病
人口
基因表达调控
氧化应激
DNA损伤
基因
基因表达
生物信息学
遗传学
神经科学
DNA
医学
免疫学
内科学
内分泌学
哲学
认识论
环境卫生
作者
Bin Feng,Junli Zheng,Ying Cai,Yaguang Han,Han Ye,Jilei Wu,J. Feng,Kai Zheng
出处
期刊:Actas Espanolas De Psiquiatria
日期:2024-06-05
卷期号:52 (3): 365-374
标识
DOI:10.62641/aep.v52i3.1595
摘要
Alzheimer's disease (AD), the most common form of dementia, has a complex pathogenesis. The number of AD patients has increased in recent years due to population aging, while a trend toward a younger age of onset has arisen, imposing a substantial burden on society and families, and garnering extensive attention. DNA methylation has recently been revealed to play an important role in AD onset and progression. DNA methylation is a critical mechanism regulating gene expression, and alterations in this mechanism dysregulate gene expression and disrupt important pathways, including oxidative stress responses, inflammatory reactions, and protein degradation processes, eventually resulting in disease. Studies have revealed widespread changes in AD patients' DNA methylation in the peripheral blood and brain tissues, affecting multiple signaling pathways and severely impacting neuronal cell and synaptic functions. This review summarizes the role of DNA methylation in the pathogenesis of AD, aiming to provide a theoretical basis for its early prevention and treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI