吡喃酮
三环
立体化学
青霉属
化学
内生真菌在植物防御中的应用
生药学
生物活性
生物
植物
体外
生物化学
食品科学
作者
Yan Bai,Xiaodong Ma,Dechun Ren,Yu Gao,Jiangchun Hu,Hui‐Ming Hua,Huaqi Pan
标识
DOI:10.1021/acs.jnatprod.4c00383
摘要
Five cyclopenta[d]pyrano[4,3-b]pyran-1,7(6H)-dione 6/6/5-fused tricyclic ring system containing metabolites peniapyrones A–E (1–5), and four previously undescribed cyclopenta[4,5]furo[3,2-c]pyran-1-one 6/5/5-fused tricyclic ring system containing compounds peniapyrones F–I (6–9), were isolated from the endophytic Penicillium brefeldianum F4a. Their structures, including absolute configurations, were determined through spectroscopic analysis and quantum chemical calculations. Peniapyrones D (4) and E (5) were a pair of diastereoisomers. Compounds 1, 3, and 5–9 showed cytotoxic activity against AsPC-1, CRL-2234, and MCF-7 cancer cell lines. Compounds 1, 3, 6, 8, and 9 inhibited the Kirsten rat sarcoma viral oncogene homologue (KRAS) mutant AsPC-1 cell line.
科研通智能强力驱动
Strongly Powered by AbleSci AI