Nanomedicine is a most promising application of medicinal nanotechnology with the aid of a molar device and microscopic information of human physiology. Nanorobotics is a miniature engine intended to achieve definite functions continually with precision at nanoscale dimensions. These nanodevices will be utilized in humans to maintain health and defend against pathogens. Fluorescence is a technique that merges with biologically driven nanorobots to produce real-time imaging. Nanorobots provide and efficient carrier of the therapeutic agent coupled with targeting ligands partially accomplish the concept of a “magic bullet.” This chapter emphasizes targeted drug delivery with nanorobots for a speedy recovery and to improve the efficiency of the therapeutic agent in the area of interest. In nanorobotics, enzymatic nanolithography plays a crucial role in the target delivery of therapeutic agents. Robotics can reduce the problems encountered with complex surgery expand the range of a medical practitioner.