The 3D printed conductive grooved topography hydrogel combined with electrical stimulation for synergistically enhancing wound healing of dermal fibroblast cells

佩多:嘘 材料科学 自愈水凝胶 生物医学工程 伤口愈合 再生(生物学) 聚苯乙烯磺酸盐 组织工程 生物材料 皮肤修复 复合材料 纳米技术 高分子化学 聚合物 外科 细胞生物学 医学 生物
作者
Jian‐Jr Lee,Hooi Yee Ng,Yen-Hong Lin,En‐Wei Liu,Ting‐Ju Lin,Hsiang-Ting Chiu,Xin-Rong Ho,Hsi-An Yang,Ming‐You Shie
出处
期刊:Biomaterials advances 卷期号:142: 213132-213132 被引量:21
标识
DOI:10.1016/j.bioadv.2022.213132
摘要

Patients with extensive cutaneous damage resulting from poor wound healing often have other comorbidities such as diabetes that may lead to impaired skin functions and scar formation. Many recent studies have shown that the application of electrical stimulation (ES) to cutaneous lesions significantly improves skin regeneration via activation of AKT intracellular signaling cascades and secretion of regeneration-related growth factors. In this study, we fabricated varying concentrations of gelatin-methacrylate (GelMa) hydrogels with poly(3,4-ethylenedioxythiophene) (PEDOT): polystyrene sulfonate (PSS), which is a conductive material commonly used in tissue engineering due to its efficiency among conductive thermo-elastic materials. The results showed successful modification of PEDOT:PSS with GelMa while retaining the original structural characteristics of the GelMa hydrogels. In addition, the incorporation of PEDOT:PSS increased the interactions between both the materials, thus leading to enhanced mechanical strength, improved swelling ratio, and decreased hydrophilicity of the scaffolds. Our GelMa/PEDOT:PSS scaffolds were designed to have micro-grooves on the surfaces of the scaffolds for the purpose of directional guiding. In addition, our scaffolds were shown to have excellent electrical conductivity, thus leading to enhanced cellular proliferation and directional migration and orientation of human dermal fibroblasts. In vivo studies revealed that the GelMa/PEDOT:PSS scaffolds with electrical stimulation were able to induce full skin thickness regeneration, as seen from the various stainings. These results indicate the potential of GelMa/PEDOT:PSS as an electro-conductive biomaterial for future skin regeneration applications.
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