Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?

Dermatologic TherapyVolume 34, Issue 2 e14835 ORIGINAL ARTICLE Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers? Tubanur Çetinarslan, Tubanur Çetinarslan orcid.org/0000-0002-2847-9127 Department of Dermatology, Manisa City Hospital, Manisa, TurkeySearch for more papers by this authorAylin Türel Ermertcan, Corresponding Author Aylin Türel Ermertcan draylinturel@hotmail.com orcid.org/0000-0001-7720-5491 Medical Faculty, Department of Dermatology, Manisa Celal Bayar University, Manisa, Turkey Correspondence Aylin Türel Ermertcan, Uncubozkoy Mah. 5501 Sok. 29/5 Manisa, Turkey. Email: draylinturel@hotmail.comSearch for more papers by this authorBeyhan Özyurt, Beyhan Özyurt Department of Public Health, Manisa Celal Bayar University, Manisa, TurkeySearch for more papers by this authorKamer Gündüz, Kamer Gündüz orcid.org/0000-0002-1319-9237 Medical Faculty, Department of Dermatology, Manisa Celal Bayar University, Manisa, TurkeySearch for more papers by this author Tubanur Çetinarslan, Tubanur Çetinarslan orcid.org/0000-0002-2847-9127 Department of Dermatology, Manisa City Hospital, Manisa, TurkeySearch for more papers by this authorAylin Türel Ermertcan, Corresponding Author Aylin Türel Ermertcan draylinturel@hotmail.com orcid.org/0000-0001-7720-5491 Medical Faculty, Department of Dermatology, Manisa Celal Bayar University, Manisa, Turkey Correspondence Aylin Türel Ermertcan, Uncubozkoy Mah. 5501 Sok. 29/5 Manisa, Turkey. Email: draylinturel@hotmail.comSearch for more papers by this authorBeyhan Özyurt, Beyhan Özyurt Department of Public Health, Manisa Celal Bayar University, Manisa, TurkeySearch for more papers by this authorKamer Gündüz, Kamer Gündüz orcid.org/0000-0002-1319-9237 Medical Faculty, Department of Dermatology, Manisa Celal Bayar University, Manisa, TurkeySearch for more papers by this author First published: 01 February 2021 https://doi.org/10.1111/dth.14835Citations: 5Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Hidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating skin disease. Recent studies showed that inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Lymphocyte/HDL ratio (LHR), Neutrophil/HDL ratio (NHR), and Monocyte/HDL ratio (MHR) are an indicator of inflammatory diseases and may be associated with disease severity and disease activity. To investigate NLR, PLR, LHR, NHR, and MHR in HS patients. In addition, to compare erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, leukocyte profile, and biochemical parameters between the control and the patient group. Clinical and biochemical data of patients and healthy subjects were collected from medical records, retrospectively. In total, 166 patients with HS and 124 control subjects were included. We found no significant difference in NLR (P = .207) and PLR (P = .257). LHR (P < .001), NHR (P < .001), and MHR (P < .001) were significantly higher in the patient group. No positive correlation was found between any of these markers and disease severity according to Hurley staging system. However, MCV (Mean corpuscular volume), RDW (Red cell distribution width), and CRP showed a significant positive correlation with disease severity. Among these markers, only MHR was positively correlated with disease duration. Our study shows that CRP still maintains its value for HS patients compared to new inflammation markers. Unlike the studies in other inflammatory diseases, no significant relationship was found with most of these inflammatory parameters. MHR may be more useful in patients with HS as an indicator of inflammation compared to other parameters. CONFLICT OF INTEREST The authors declare no conflict of interest. Open Research DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. Citing Literature Volume34, Issue2March/April 2021e14835 RelatedInformation