缺血
小RNA
再灌注损伤
医学
移植
生物标志物
器官移植
肝移植
肾
生物信息学
病理
基因
内科学
生物
生物化学
作者
Fatemeh Sabet Sarvestani,Negar Azarpira,Ismail H. Al-Abdullah,Ali‐Mohammad Tamaddon
标识
DOI:10.1016/j.biopha.2020.110944
摘要
Ischemia reperfusion injury (IRI) is a condition that occurs wherever blood flow and oxygen is reduced or absent, such as trauma, vascular disease, stroke, and solid organ transplantation. This condition can lead to tissue damage, especially during organ transplantation. Under such circumstances, some signaling pathways are activated, leading to up- or down- regulation of several genes such as microRNAs (miRNAs) that might attenuate or ameliorate this status. Therefore, by manipulating miRNAs level, they can be used as a biomarker for early diagnosis of IRI or suggestive to be therapeutic agents in clinical situation in future.
科研通智能强力驱动
Strongly Powered by AbleSci AI