表观遗传学
循环肿瘤细胞
转移
生物标志物
癌症
癌症转移
肿瘤异质性
医学
癌症研究
生物
内科学
基因
生物化学
作者
Sai Shyam Vasantharajan,Michael R. Eccles,Euan J. Rodger,Sharon Pattison,John McCall,Elin S. Gray,Leslie Calapre,Aniruddha Chatterjee
标识
DOI:10.1016/j.bbcan.2021.188514
摘要
Cancer metastasis is the main reason for the high mortality in patients, contributing to 90% of cancer-related deaths. Biomarkers for early detection and therapeutic monitoring are essential to improve cancer outcomes. Circulating tumour cells (CTCs) arise from solid tumours and are capable of metastatic dissemination via the bloodstream or lymphatic system. Thus, CTCs can potentially be developed as a minimally invasive biomarker for early detection and therapeutic monitoring. Despite its clinical potential, research on CTCs remains limited, and this is likely due to their low numbers, short half-life, and the lack of robust methods for their isolation. There is also a need for molecular characterisation of CTCs to identify tumour-specific features, such as epigenetic signatures of metastasis. This review provides an overview of the epigenetic landscape of CTCs. We discuss the role of epigenetic modifications in CTC dissemination,metastatic tumour formation and progression and highlight its clinical implications
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