免疫佐剂
化学
纳米颗粒
介孔二氧化硅
介孔材料
表面改性
佐剂
纳米技术
组合化学
材料科学
有机化学
催化作用
医学
内科学
物理化学
作者
Manasi Jambhrunkar,Yannan Yang,Meihua Yu,M. Zhang,Prasanna Lakshmi Abbaraju,Trisha Ghosh,Mohammad Kalantari,Yue Wang,Nigel A.J. McMillan,Chengzhong Yu
标识
DOI:10.1016/j.mtadv.2020.100069
摘要
Nanomaterials have provided an emerging solution to improve the efficacy of cancer vaccines against malignant tumors. However, developing nanoparticles possessing both potent immunoadjuvant and co-delivery activities without tedious functionalization remains challenging. In the present work, we report that pristine benzene-bridged mesoporous organosilica nanoparticles are a novel immunoadjuvant and co-delivery platform for both antigen and cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG, a toll-like receptor 9 agonist). It is shown that the chemical compositions of bridged organosilica framework (–Si–R–Si–OH, R = benzene, ethylene) have a significant impact on their functionalities. When benzene bridge groups are present in the framework, pristine nanoparticles with large mesopores and high pore volumes are able to stimulate the maturation of dendritic cells, and efficiently co-encapsulate ovalbumin (OVA) and CpG for delivery into immune cells, leading to a superior tumor inhibition performance in an aggressive OVA-expressed B16F10 melanoma model, with 100% tumor-free mice in 25 days. Our study provides new knowledge in the design of effective cancer nanovaccines.
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