共核细胞病
路易氏体型失智症
医学
α-突触核蛋白
皮肤活检
尸检
萎缩
帕金森病
活检
路易体
神经学
痴呆
生物标志物
疾病
病理
生物
精神科
生物化学
作者
Zerui Wang,Katelyn Becker,Vincenzo Donadio,Sandra L. Siedlak,Jue Yuan,Masih Rezaee,Alex Incensi,Anastasia Kuzkina,Christina D. Orrù,Curtis Tatsuoka,Rocco Liguori,Steven A. Gunzler,Byron Caughey,María E. Jiménez‐Capdeville,Xiongwei Zhu,Kathrin Doppler,Li Cui,Shu G. Chen,Jiyan Ma,Wen‐Quan Zou
出处
期刊：JAMA Neurology
[American Medical Association]
日期：2020-09-28
卷期号：78 (1): 30-30
被引量：175
标识
DOI：10.1001/jamaneurol.2020.3311
摘要
Deposition of the pathological α-synuclein (αSynP) in the brain is the hallmark of synucleinopathies, including Parkinson disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). Whether real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA) assays can sensitively detect skin biomarkers for PD and non-PD synucleinopathies remains unknown.
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