[Significance of Neutrophil/Lymphocyte Ratio in the Prognosis of Patients with Multiple Myeloma].

To study the value of neutrophil/lymphocyte ratio (NLR) in the evaluation of prognosis of patients with multiple myeloma (MM).NLR was calculated on the basis of the blood routine examination results of 65 patients with primary MM (MM group) and 83 persons receiving physical examination as control group, and the difference in 2 group was compared; moreover according to the median as threshold, the patients were divided into low NLR group (NLR＜2.34) and high NLR group (NLR≥2.34); the differences of age, sex, serum calcium β2 (Ca), microglobulin (β2-MG), albumin (Alb), serum creatinine (Cr), hemoglobin (Hb), red blood cell distribution width (RDW) and lactate dehydrogenase (LDH) in 2 group were analyzed, and the survival rate was compared between the high and low-NLR group.the NLR of MM patients was statistically significantly higher than that of the control group (z=-2.415, P＜0.05). Compared with the low NLR group, the β2-MG and Cr levels of patients in the high NLR group seemed higher, but the difference was not statistically significant. The single-factor analysis showed that NLR, β2-MG and Alb levels were risk factors for the prognosis of MM patients, and the multi-factor analysis showed that NLR and Alb level were independent risk factors influencing the prognosis of MM patients.NLR elevation in patients with primary diagnosis of MM indicates a poor prognosis, which is an independent risk factor affecting the prognosis.中性粒细胞/淋巴细胞比值在多发性骨髓瘤患者预后中的意义.探讨中性粒细胞/淋巴细胞比值（NLR）对多发性骨髓瘤（MM）患者预后评估的价值.以65例初发MM患者和83例同期健康体检者，根据血常规结果计算得出NLR，比较2者差异；并以中位数为临界值，将病例组患者分为低NLR组（NLR＜2.34）和高NLR组（NLR≥2.34），分析2组患者在年龄、性别、血清钙（Ca）、血清β2微球蛋白（β2-MG）、白蛋白（Alb）、血肌酐（Cr）、血红蛋白（Hb）、红细胞分布宽度（RDW）及乳酸脱氢酶（LDH）水平的差异；比较高NLR组和低NLR组患者生存率的差异；单因素及COX多因素回归分析各指标与MM患者预后的关系.MM患者NLR水平高于对照组（z=-2.415，P ＜0.05）；与低NLR组相比，高NLR组患者β2-MG 及Cr水平偏高，但差异无统计学意义；单因素分析结果显示，NLR、β2-MG及ALB是MM患者预后的危险因素；多因素分析显示，NLR及Alb水平是影响MM患者预后的独立危险因素.初诊MM患者NLR升高提示预后不良，是影响预后的独立危险因素.