化学
硫黄
组分(热力学)
组合化学
选择性
反应条件
有机化学
催化作用
热力学
物理
作者
Xingxing Ma,Xiaoning Yu,Hua Huang,Yao Zhou,Qiuling Song
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-06-30
卷期号:22 (14): 5284-5288
被引量:58
标识
DOI:10.1021/acs.orglett.0c01275
摘要
A three-component strategy for the synthesis of thiazoles and isothiazoles has been developed by employing enaminoesters, fluorodibromoiamides/ester, and sulfur. The thiazoles and isothiazoles were formed via two C–F bond cleavages along with the formation of new C–S, C–N, and N–S bonds. The strategy provides high selectivity for the synthesis of thiazoles/isothiazoles, which have vital applications in drug discovery and development.
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