钛酸钙
脚手架
钙
热液循环
化学
活力测定
生物物理学
材料科学
水热合成
体内
纳米技术
生物医学工程
化学工程
细胞
生物化学
冶金
陶瓷
生物
生物技术
工程类
医学
作者
Haoyan Cheng,Hao Hu,Guang Li,Meng Zhang,Kaiwen Xiang,Zhihong Zhu,Ying Wan
标识
DOI:10.1016/j.cej.2020.124400
摘要
Calcium ion (Ca2+) has received great attention in recent years in the field of bone implant materials because of its vital role in osteogenesis. A micro-sheet structured calcium titanate (CaTiO3) scaffold is designed and fabricated through a two-step hydrothermal method and ions exchange method. The success of this synthesis relies on the ions exchange process to facilitate the conversion of Na0.8H1.2Ti3O7 to H2Ti3O7. The CaTiO3 scaffold with uniform surface morphology and interconnected space can be obtained after a second hydrothermal reaction between H2Ti3O7 and Ca(OH)2 at 180 °C for 4 h. SEM images, MTT and ALP assays evidence that the obtained material shows a Ca-dose-dependent enhancement for the attachment, proliferation, and differentiation of MC3T3-E1 cells. Fluorescence images indicated that MS/Ca180 with the highest Ca content greatly promote cell's migration behavior. In addition, the sufficient Ca content in the CaTiO3 scaffold can provide a Ca source for new bone formation, which accelerates the osteogenesis in vivo. This novel CaTiO3 scaffold holds great promise to promote the defective bone repair by offering a morphologically and compositionally appropriate microenvironment.
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