橙皮素
炎症
西妥因1
奶油
脂多糖
安普克
化学
激活剂(遗传学)
乙酰化
药理学
免疫学
生物
生物化学
类黄酮
下调和上调
转录因子
磷酸化
蛋白激酶A
受体
基因
抗氧化剂
作者
Siwei Wang,Wen Wang,Hao Sheng,Yang Bai,Yuanyuan Weng,Xueyu Fan,Fang Zheng,Xin-tian Zhu,Zheng-Cai Xu,Feng Zhang
标识
DOI:10.1016/j.intimp.2020.107036
摘要
Silent mating type information regulation 2 homolog 1 (SIRT1) is an important inflammatory regulator, which epigenetically reprograms inflammation by altering the acetylation of NF-κB. Hesperetin, as a common flavonoid, has been proven to have a significant effect on acute inflammatory diseases. However, the detailed molecular mechanism by which hesperetin alleviates inflammatory response and accompanied tissue injury is poorly understood. Our results show that SIRT1 is required for the inhibitory effect of hesperetin on inflammation. Hesperetin suppresses the acetylation of RelA/p65 to reduce NF-κB activity by inducing SIRT1 expression. Mechanistically, hesperetin increases SIRT1 expression through AMPK/CREB pathway. Additionally, the protective effect of hesperetin against LPS/D-GalN-induced hepatitis in mice is also dependent on SIRT1. Our study suggests that hesperetin is an SIRT1 activator and could be potential candidates for the treatments of inflammatory conditions.
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