Abstract With the rapid development of the aviation market and the capacity limitations of aviation systems, runway intrusion has received increasing attention from the aviation community. Through the analysis of the possibility of runway incursions during the operation of Wuhan Tianhe International Airport, an algorithm for effectively preventing runway intrusion has been studied. Aiming at the many influencing factors of runway incursion, an improved runway intrusion algorithm has been proposed. Improved runway intrusion algorithm, applying flight performance and planning related knowledge to establish mathematical model, the physical properties of aircraft, such as type, wake, braking time, braking time after braking, as well as conflicting multiple zones, the slope of runway, pilot judgment reaction time, etc, these factors are all included in the consideration, so that the accuracy can be improved by setting different speed functions for different models. The simulation of the operation of the aircraft at Wuhan Tianhe International Airport has been carried out. The simulation results show that the model can give the alarm of runway intrusion and the reasonable solutions in time, which can effectively provide the assistants with decision-making.