Comparison between in vitro radiosensitivity and in vivo radioresponse in murine tumor cell lines II: in vivo radioresponse following fractionated treatment and in vitro/in vivo correlations

体内 辐射敏感性 体外 放射生物学 核医学 生存分析 医学 放射治疗 病理 生物 内科学 生物化学 生物技术
作者
Robert G. Bristow,Richard P. Hill
出处
期刊:International Journal of Radiation Oncology Biology Physics [Elsevier]
卷期号:18 (2): 331-345 被引量:79
标识
DOI:10.1016/0360-3016(90)90098-5
摘要

Survival in the low-dose region of in vitro radiation survival curves for human tumor cell lines may be correlated with the expected clinical radiocurability of tumors of similar histopathological type. The present investigation examined this hypothesis using a series of transplantable murine solid tumors. The in vivo radioresponse of the tumors following fractionated dose (10 fractions of 2 Gy given at 4 hr intervals) and single dose (20 Gy) radiation treatment was measured by growth delay and tumor cell survival assays. The measurements of tumor cell survival were initiated either immediately or 8 hr after the end of radiation treatment. There was no evidence for repair of potentially lethal damage in vivo in any of the tumors. The measurements of in vivo response were compared to parameters of in vitro radiation survival curves for the same tumor cell lines, which were measured concurrently. The tumor cell survival following 10 fractions of 2 Gy correlated best with the measured in vitro survival at 2 Gy, although good correlations were also observed with two parameters calculated from the in vitro data; the value of α from fitting the linear-quadratic (LQ) model and the mean inactivation dose (MID). Correlations were also observed between specific growth delay measured in vivo following 10 fractions of 2 Gy and these in vitro parameters. Despite the correlations observed, the measured survival values following 10 fractions of 2 Gy in vivo did not agree quantitatively with the theoretical values predicted from the in vitro survival data assuming equal effect for each fraction. This discrepancy indicates that other factors also contribute to the overall response of a tumor to fractionated irradiation. Nevertheless, these findings support the idea that intrinsic radiosensitivity plays a significant role in determining the overall response of a tumor to fractionated irradiation and provides strong support for the concept of testing the in vitro radiation sensitivity of biopsy specimens as a predictive assay of clinical radiocurability.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
kevinjy完成签到,获得积分10
1秒前
2秒前
moonlight完成签到,获得积分10
3秒前
sad完成签到,获得积分10
3秒前
底物发布了新的文献求助10
3秒前
3秒前
仁爱听露完成签到 ,获得积分10
4秒前
4秒前
东东完成签到,获得积分20
4秒前
一枪入魂完成签到,获得积分10
4秒前
4秒前
qq发布了新的文献求助10
4秒前
SKZ完成签到,获得积分10
5秒前
summer完成签到 ,获得积分10
6秒前
6秒前
大模型应助滴滴答采纳,获得10
6秒前
6秒前
桐桐应助苹果路人采纳,获得10
6秒前
大胆香彤发布了新的文献求助10
7秒前
跳跃小馒头完成签到,获得积分10
7秒前
李善聪完成签到,获得积分10
7秒前
7秒前
松本润不足完成签到,获得积分10
7秒前
ZIS完成签到,获得积分10
7秒前
呜呜咔咔完成签到,获得积分10
7秒前
玩命的水池完成签到,获得积分10
7秒前
标致乐双完成签到,获得积分10
8秒前
Lucy完成签到,获得积分10
8秒前
A溶大美噶发布了新的文献求助10
8秒前
9秒前
9秒前
底物完成签到,获得积分10
10秒前
空白完成签到,获得积分10
10秒前
小蘑菇应助孙文杰采纳,获得10
10秒前
大气乘风发布了新的文献求助10
10秒前
111发布了新的文献求助10
10秒前
俊逸的代曼完成签到,获得积分10
10秒前
xxx完成签到 ,获得积分10
11秒前
11秒前
11秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
Shining Light on the Dark Side of Personality 400
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3307802
求助须知:如何正确求助?哪些是违规求助? 2941301
关于积分的说明 8502750
捐赠科研通 2615835
什么是DOI,文献DOI怎么找? 1429200
科研通“疑难数据库(出版商)”最低求助积分说明 663673
邀请新用户注册赠送积分活动 648644