DPPH
生物碱
化学
抗氧化剂
抗菌剂
传统医学
茜草科
最小抑制浓度
食品科学
植物
生物
有机化学
医学
作者
Suhanya Parthasarathy,Juzaili Azizi,Surash Ramanathan,Sabariah Ismail,Sreenivasan Sasidharan,Mohd Ikram Mohd Said,Sharif Mahsufi Mansor
出处
期刊:Molecules
[Multidisciplinary Digital Publishing Institute]
日期:2009-10-09
卷期号:14 (10): 3964-3974
被引量:157
标识
DOI:10.3390/molecules14103964
摘要
Studies on the antioxidant and antimicrobial activities of Mitragyna speciosa leaf extracts are lacking. In this study the antioxidant properties of water, methanolic and alkaloid M. speciosa leaf extracts were evaluated using the DPPH (2,2-diphenyl-1- picrylhydrazyl) radical scavenging method. The amount of total phenolics and flavanoid contents were also estimated. The DPPH IC50 values of the aqueous, alkaloid and methanolic extracts were 213.4, 104.81 and 37.08 μg/mL, respectively. The total phenolic content of the aqueous, alkaloid and methanolic extracts were 66.0 mg, 88.4, 105.6 mg GAE/g, respectively, while the total flavanoid were 28.2, 20.0 and 91.1 mg CAE/g respectively. The antioxidant activities were correlated with the total phenolic content. This result suggests that the relatively high antioxidant activity of the methanolic extract compared to aqueous and alkaloid extract could be possibly be due to its high phenolic content. The aqueous, alkaloid and methanolic extracts were screened for antimicrobial activity. The extracts showed antimicrobial activity against Salmonella typhi and Bacillus subtilis. The minimum inhibitory concentrations (MICs) of extracts determined by the broth dilution method ranged from 3.12 to 6.25 mg/mL. The alkaloid extract was found to be most effective against all of the tested organisms.
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