Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities

ChemBioChemVolume 10, Issue 14 p. 2311-2315 Communication Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: Prediction with mRNA Expression, Chemical Synthesis, and Immunostimulatory Activities Yukari Fujimoto Prof. Dr., Yukari Fujimoto Prof. Dr. Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5391Search for more papers by this authorMasahito Hashimoto Prof. Dr., Masahito Hashimoto Prof. Dr. Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima 890-0065 (Japan)Search for more papers by this authorMaiko Furuyashiki, Maiko Furuyashiki Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima 890-0065 (Japan)Search for more papers by this authorMami Katsumoto, Mami Katsumoto Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5391Search for more papers by this authorTsukasa Seya Prof. Dr., Tsukasa Seya Prof. Dr. Venture Business Laboratory, Kagoshima University, Kagoshima 890-0065 (Japan)Search for more papers by this authorYasuo Suda Prof. Dr., Yasuo Suda Prof. Dr. Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima 890-0065 (Japan) Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638 (Japan)Search for more papers by this authorKoichi Fukase Prof. Dr., Koichi Fukase Prof. Dr. koichi@chem.sci.osaka-u.ac.jp Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5391Search for more papers by this author Yukari Fujimoto Prof. Dr., Yukari Fujimoto Prof. Dr. Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5391Search for more papers by this authorMasahito Hashimoto Prof. Dr., Masahito Hashimoto Prof. Dr. Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima 890-0065 (Japan)Search for more papers by this authorMaiko Furuyashiki, Maiko Furuyashiki Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima 890-0065 (Japan)Search for more papers by this authorMami Katsumoto, Mami Katsumoto Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5391Search for more papers by this authorTsukasa Seya Prof. Dr., Tsukasa Seya Prof. Dr. Venture Business Laboratory, Kagoshima University, Kagoshima 890-0065 (Japan)Search for more papers by this authorYasuo Suda Prof. Dr., Yasuo Suda Prof. Dr. Department of Nanostructure and Advanced Materials, Kagoshima University, Kagoshima 890-0065 (Japan) Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638 (Japan)Search for more papers by this authorKoichi Fukase Prof. Dr., Koichi Fukase Prof. Dr. koichi@chem.sci.osaka-u.ac.jp Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5391Search for more papers by this author First published: 15 September 2009 https://doi.org/10.1002/cbic.200900242Citations: 18Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Recognize this? Based on predictions from mRNA expression of lipoproteins from Staphylococcus aureus, lipopeptide fragments were chemically synthesized, and their TLR2-stimulatory activities and cytokine-induction capabilities were analyzed. All the lipopeptides activated TLR2, but the activities varied depending on their peptide sequences. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description cbic_200900242_sm_miscellaneous_information.pdf66.6 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume10, Issue14September 21, 2009Pages 2311-2315 RelatedInformation