药物发现
骨骼肌
药品
心肌
计算生物学
医学
计算机科学
药物开发
生物信息学
药理学
生物
解剖
作者
Mohammad Hossein Mohammadi,Raquel Obregón,Samad Ahadian,Javier Ramón-Azcón,Milica Radisic
标识
DOI:10.2174/1381612823666170215115445
摘要
Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed. Keywords: Cardiac muscle, Skeletal muscle, drug screening, Engineering muscle, Human pharmacological response, physiological similarity.
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