Comparison of autologous platelet‐rich plasma with autologous serum eye drop in corneal epithelial disorder

Purpose To compare Autologous Platelet‐Rich Plasma (PRP) with Autologous Serum Eye Drop(ASED)in corneal persistent epithelial defect. Methods 35 eyes of 32 patients with persistent epithelial defect at the Khatam_AL_Anbia eye hospital of Mashhad medical science university between 2012 and 2014 enrolled in the study, randomly. Nineteen eyes treated by PRP and 16 eyes treated by ASED 20%. The treatment applied for patients with persistent epithelial defect that didn't respond to any other conventional therapy. Patients examined before, 1 week and 1 month after the treatment. Examination include BCVA, symptoms pain and photophobia), and slit lamp examination including defect size. Results In PRP‐treated group, 9 patients had complete healing, 6 eyes had partial healing and treatment failed in two patients (4 eyes). In ASED group, 6 patients healed completely, 10 patients partially healed and no patient was failed to treat. There was no significant difference in BCVA, pain, photophobia and slit lamp parameters between two groups before and after treatment. The healing rate was faster in PRP group. Conclusions ASED and PRP both are effective in corneal epithelial defect. This study showed no significant difference between these two medications.